Anti-Aging Diet: Prolonging Youthfulness Through Nutrition

We’ve all heard the saying, “You are what you eat.” It emphasizes that our eating habits are highly connected to our overall health and well-being. 

Doctors, dietitians, and nutritionists frequently recommend diets for specific health concerns like cholesterol or blood sugar levels. Yet, what’s oftentimes overlooked is the comprehensive concept of improving or even preventing ill health by using nutrition to promote longevity and anti-aging. 

You see, being healthy and staying youthful are intertwined, and our daily eating habits play a significant role in maintaining both. 

At RELATYV, we believe that addressing health and longevity separately is part of a problematic and fragmented health system. We strive to challenge this norm, believing that a consolidated approach is vital for helping individuals understand how to improve both their vitality and longevity.

We’re here to share insights into a topic rarely discussed throughout conventional medicine – the connection between anti-aging, wellness, and nutrition. 

In this guide, we’ll explore the transformative power of nutrition at a cellular level to roll back your biological age and support overall health. We hope to help you understand the fundamental concepts of anti-aging diets and mindful diet choices in order to achieve lasting good health and youthfulness.

Understanding The Concept Of Anti-Aging Diets

Biological aging is a complex physiological process influenced by factors like stress, poor diets, and harmful toxins or pollutants. Ongoing exposure to these factors can cause chronic inflammation throughout the body and accelerate the biological aging processes, most notably the senescence process. 

Senescence is a key contributor to biological aging as it impacts cell division and overall cell function. Increased senescence, in turn, “ages” the body’s tissues and organs, diminishing their capacity. 

This functional decline is what presents as the visible signs of aging, being changes in skin appearance, reduced mobility and energy, cognitive decline, and an increased risk of developing disease. 

Shakti, Ritu & Dubey (2016) point out that a significant portion of health issues in people over 65 is linked to diet, making it crucial to understand the impact of our daily eating habits on our biological age.

Carefully designed anti-aging diets aim to combat cellular aging by recognizing the profound impact of daily food choices on molecular and metabolic functioning, influencing how we look, feel, and age. They promote robust cellular repair, protecting against inflammation-induced damage to slow senescence and biological aging.

This brings us to the discussion of how the nutritious elements of an anti-aging diet directly influence our digestion and gut microbiota. We’ll talk about how this connection plays a crucial role in the aging process.

The Influence Of Nutrition And Gut Microbiota On Aging

You’ve probably heard about the gut microbiome, which is a bustling community of billions of microbes living in the digestive tract. These microbes are gaining significant attention for their crucial role in various biological processes. In the last two decades, one of the most groundbreaking discoveries has been their intricate relationship with nutrition, gut health, and the aging process.

Each person’s gut microbiome is unique, and maintaining its health and stability is crucial to avoid imbalances. This is because an imbalance can lead to issues in the digestive lining, allowing pro-inflammatory substances into the bloodstream and spreading inflammation throughout the body. 

Chronic systemic inflammation is known to be harmful, contributing to various health issues, speeding up aging, and paving the way for chronic diseases.

Studies suggest the gut microbiome has a direct influence on aging. As we age, there’s a shift from a healthy to an aged microbiome, which is marked by reduced biota diversity. Poor diversity may trigger physiological changes, chronic inflammation, and a decline in immune and metabolic function. This then sets the stage for age-related conditions and a less robust immune defense.

The good news is that we can support the health of our gut microbiota through our diet. An anti-aging diet rich in antioxidants and a balance of proteins, fats, carbs, and essential nutrients is pivotal in shaping and maintaining a balanced and healthy gut microbiota and ultimately fostering overall well-being and longevity.

Essentially, safeguarding our biological age is significantly influenced by the interplay between nutrition and our gut microbiota. In the next section, we’ll look into the specific anti-aging foods that nurture this relationship and promote both health and longevity.

Key Components Of An Anti-Aging Diet

The secrets of an effective anti-aging diet involve embracing a variety of delicious and nourishing foods. The following foods supply the gut microbiota and the body with essential nutrients, optimizing cellular processes and guarding against harmful inflammation.

Antioxidant-Rich Foods

Antioxidants are well known for their role in combating oxidative stress, neutralizing harmful free radicals that contribute to cellular damage, and aging. They are found abundantly in fruits and vegetables such as berries, spinach, and nuts.

Omega-3 Fatty Foods

Fatty fish such as salmon, chia seeds, and flaxseeds are high in omega-3 fatty acids, a powerful nutrient that promotes heart health and cognitive function. 

These healthy fats have also been shown to play a key role in reducing senescence in human immune cells, allowing them to function better for longer and contributing to their longevity.

Lean Proteins

Proteins are your body’s essential building blocks. Opting for lean sources such as poultry, tofu, and legumes ensures that you get the necessary amino acids without excess saturated fats. 

Protein is necessary to sustain energy levels, preserve muscle mass, and support a number of physiological processes, particularly as we age and strive to prevent frailty.

Collagen-Rich Foods

Collagen, the body’s beauty secret, isn’t just for radiant skin. In fact, it’s the body’s most abundant protein. It plays a crucial role in supporting bone and joint health, as well as contributing to the strength and flexibility of muscles and connective tissues. 

As we age, the body produces less collagen. Incorporating collagen-rich foods such as bone broth, chicken skin, and fish into your diet can boost your system’s collagen. Much like other proteins, this important nutrient works to reduce frailty and bone-related diseases throughout aging.

Whole Grains

Swap refined grains for whole grains like quinoa, brown rice, and oats. These nutrient-dense foods are rich in prebiotic fibers, vitamins, and minerals, offering sustained energy and supporting a healthy gut microbiome

Whole grains are also recommended to help stabilize blood sugar levels, a key factor in preventing many age-related health issues.

High-Fiber Foods

Aside from whole grains, fruits, vegetables, and legumes are excellent sources of fiber. A balanced diet with adequate fiber not only promotes good digestive health and managing a healthy weight but it’s also known to decrease harmful inflammation and help modulate the immune system.

Hydration

Drinking enough water is extremely valuable to your overall health and is fundamental to an anti-aging lifestyle. But most adults fall short of the daily recommended six to eight glasses of water.

Staying well-hydrated flushes out toxins, keeps the skin radiant, and supports your bodily functions right down to the cellular level. So, keep a bottle handy and make it a habit to sip water throughout the day.

It’s exciting to discover that incorporating these vital nutritional components not only reduces the risk of chronic diseases but also plays a role in preventing cellular senescence. Ongoing research into the perfect ratios for optimal health and longevity adds to the anticipation of unlocking secrets to graceful aging.

In the following section, we’ll explore some of the popular diets supporting anti-aging concepts and the research behind them.

Types Of Diet Plans That Promote Longevity

Several diet plans stand out in their ability to boost cellular functions and support the gut microbiome, potentially contributing to a longer, healthier life. Although the specifics of each diet may differ, they have all shown unique benefits in promoting longevity through smart nutrition.

Intermittent Fasting

Intermittent fasting involves limiting calories by cycling between eating and fasting, anywhere from 12 to 48 hours, repeating every 1-7 days. 

Research suggests that by providing the digestive system with periodic breaks, intermittent fasting improves overall metabolic health, reduces inflammation, and enhances cellular repair. It also shows potential in slowing or reversing cellular senescence in immune cells associated with aging and chronic diseases.

Fasting-Mimicking Diets

Fasting-mimicking diets (FMDs) replicate fasting’s benefits while allowing the consumption of specific foods. Lasting four to five days, it suggests eating just under half your usual calories, making it an easier choice for most people supporting their longevity.

Recommended foods include vegetables, nuts, seeds, and healthy fats like olive oil, rich in essential anti-aging components. FMDs aim to boost cellular rejuvenation, nurture the gut microbiome, and reduce risks associated with poor health, accelerated aging, and age-related diseases.

Ketogenic Diets

Ketogenic diets focus on a highly modified diet that is high-fat and very low-carbohydrate. This aims to trigger a state of ketosis, where the body switches from using carbohydrates to burning fat for energy. 

The metabolic shift seen in ketogenic diets is suggested to offer benefits such as improved cognitive function, reduced inflammation, and better weight management, all supporting your cellular health. However, some individuals find it difficult to sustain a ketogenic diet due to its significant restrictions.

Time Restricted Feeding

Unlike intermittent fasting, this approach does not actively limit a person’s overall caloric intake but only allows eating at specific times, aligned with the body’s 24-hour circadian rhythm.

This particular diet is suggested to support longevity by optimizing healthy sleep cycles as well as overall metabolic health.

Protein Restriction

Protein restriction diets aim to balance essential nutrients for improved metabolic health and enhanced cellular functions, emphasizing moderation in animal product intake specifically.

Restricting overall protein intake and opting for plant-based proteins may contribute to metabolic health and longevity effects. However, further studies are needed to clarify and rule out potential nutritional deficiencies.

Dietary Restriction Of Specific Amino Acids

Limiting certain amino acids follows similar principles to limiting overall protein intake. Specifically restricted from the diet are methionine, tryptophan, and branched-chain amino acids (BCAA).

This restriction is linked to enhanced autophagy, reduced oxidative stress, improved cellular and metabolic function, and increased longevity. However, it’s important to note that all proteins are essential for maintaining muscle mass and strength, which are other important factors of aging well.

In essence, these diets offer unique avenues to optimize cellular functions, reduce inflammation, delay senescence, and support metabolism, all integral aspects of a longer, healthier life.

Whether choosing caloric restriction like intermittent fasting, ketogenic diets, or time-restricted feeding or focusing on nutrient-specific limitations such as protein restriction or specific amino acids, each approach offers unique benefits for overall well-being.

However, before undergoing significant dietary changes, consulting your healthcare professional is vital to ensure your nutritional needs are met. Studies emphasize the importance of meeting nutritional requirements, as malnutrition could negate the benefits of healthy aging.

In the upcoming section, we explore the complementary lifestyle factors that may further support your anti-aging journey toward health and longevity.

Complementary Regimens To Enhance The Effects Of Anti-Aging Diets

To maximize the effectiveness of an anti-aging diet, incorporating additional habits can significantly enhance overall health and well-being. These complementary practices focus on a whole-person approach to longevity, addressing various aspects of a person’s lifestyle.

Longevity Supplements

Advanced nutritional supplements serve as powerful tools in fortifying the body against aging. These supplements provide essential vitamins, minerals, and antioxidants that may be challenging to obtain through diet alone. Examples include omega-3 fatty acids, vitamin D, and coenzyme Q10.

Remember, not all supplements are created equally. To maximize benefits, choose high-quality, well-researched supplements that your body can easily absorb and utilize for optimal benefit.

Embrace A Healthy Lifestyle

A healthy lifestyle is a fundamental pillar of your anti-aging journey. Prioritize physical activity, sufficient sleep, and stress management to moderate cellular processes and minimize inflammatory effects.

Additionally, regular exercise supports cardiovascular health, enhances mood, and helps maintain a healthy weight. Quality sleep is another essential aspect for cellular repair and overall well-being, while effective stress management contributes to a balanced and resilient mind-body connection.

Prioritize A Balanced Diet

While this may seem redundant in the context of an anti-aging diet article, highlighting the continued importance of a balanced diet is crucial.

Beyond specific anti-aging components, a diet rich in diverse nutrients, fruits, vegetables, and whole foods remains paramount. This habit ensures your body receives well-rounded nourishment and supports the anti-aging process from various angles. It also addresses the challenge of adhering to numerous anti-aging diets while leading a busy and varied lifestyle.

Read Labels And Eat Mindfully

Practice mindful eating by paying attention to food choices, eating slowly, and being aware of overall intake. Reading labels to understand nutritional content and potential additives is a helpful habit that can empower you to make better-informed choices. This mindful approach puts nutrition at the forefront of your mind, fostering a healthier relationship with food and supporting anti-aging goals.

Limit Alcohol And Caffeine Intake

Excessive alcohol and caffeine consumption are known to negatively impact various aspects of health, including sleep, hydration, and liver function. Limiting intake is a wise choice for those seeking to optimize anti-aging efforts. 

This doesn’t mean eliminating a daily cup of tea or coffee or a weekly glass of wine. When consumed in moderation, these substances pose fewer risks and may contribute positively to overall well-being.

Limit Processed And High-Fat Foods

Processed and high-fat foods often contain additives and unhealthy trans fats that can undermine the goals of an anti-aging diet. Limiting their intake reduces exposure to potentially harmful substances, supports cardiovascular health, and reduces the risk of stroke. Opt for whole, nutrient-dense foods as a proactive step toward enhancing the effects of anti-aging diets.

Embracing these healthy lifestyle practices not only complements an anti-aging diet but also enhances the positive impact of anti-aging efforts, nurturing your longevity and vitality as you age.

It’s strongly advised that you consult with a healthcare professional before making significant changes to your diet or lifestyle. However, many people face challenges navigating the current healthcare landscape, particularly when dealing with multiple providers. This can become a significant obstacle in your healthcare journey.

This is where RELATYV’s approach to health, anti-aging, and longevity comes into play.

RELATYV’s Approach To Anti-Aging And Longevity

After reading this, you may notice that your dietary habits have become routine, lacking essential nutrients and perhaps leading to detrimental inflammation, affecting cellular function, and extending your biological age.

At RELATYV, our unique approach involves consolidating health information to offer an integrated approach to your well-being. We don’t just help add years to your life; we prioritize adding vitality within those years by focusing on addressing biological aging through optimizing cellular functions and reducing harmful inflammation to prevent the occurrence of aging processes and age-related diseases. 

Our healthcare experience seamlessly guides your whole health journey, from exceptional service to advanced diagnostics and high-quality supplements. What’s more, our targeted education strives to empower you to make well-informed decisions that suit your unique needs and lifestyle. 

We encourage you to embark on your wellness journey with RELATYV’s expert guidance. Explore our Learning Center, your go-to hub for all things related to longevity and health.

What Is NAD+?

Nicotinamide adenine dinucleotide (NAD) is a coenzyme that is found in every living cell. It plays a crucial function in many different biological processes, including as an essential component in energy production, DNA repair, and cellular communication, which means it is vital for maintaining overall cellular health. As a result, research on NAD has been increasing, and many are now exploring its potential as a supplement for improving health and longevity.

What You Need to Know About Nicotinamide Adenine Dinucleotide (NAD)

NAD is a molecule found in all living cells and is involved in numerous cellular processes. It is a dinucleotide, meaning it is composed of two nucleotides joined together. These nucleotides are nicotinamide and adenine, which give NAD its name.

However, it’s important to differentiate NAD from NAD+. NAD+ is the raw form of NAD. NAD is first introduced into the energy production cycle as NAD+. After it is used, it becomes NADH. This means that for the body to utilize NAD, it must first be converted into its active form, NAD+.

Structure And Composition

As explained, the molecular structure of NAD consists of two nucleotides – adenine and nicotinamide, joined by a phosphate group. Adenine is an essential component of DNA and RNA. Adenine is vital to energy transfer processes, such as ATP (adenosine triphosphate) production. ATP molecules are responsible for storing and releasing energy as needed by the cells. 

On the other hand, nicotinamide is derived from vitamin B3 (niacin). Nicotinamide is responsible for carrying out redox reactions (reduction-oxidation) in cells. A redox reaction occurs when electrons are transferred from one molecule to another. This process is essential for energy generation and maintaining cellular balance. 

While there are two forms of NAD, there are also two variations of NAD+. These variations include NADP+ (nicotinamide adenine dinucleotide phosphate) and NADPH (nicotinamide adenine dinucleotide phosphate hydrogen). The following are the different types of NAD and their functions:

NAD+

NAD+ is vital to energy metabolism by acting as an electron carrier. During cellular respiration, it is involved in the conversion of glucose (the primary source of energy for our cells) into ATP. NAD+ is reduced to NADH and then later reoxidized back to its original form through a series of chemical reactions, thereby releasing energy that is used to produce ATP. This process occurs in the mitochondria, which are known as the powerhouses of our cells.

Apart from energy production, NAD+ also plays a role in DNA repair and cellular signaling. As we age, oxidative damage to our DNA accumulates, leading to mutations and potentially harmful consequences. NAD+ helps activate enzymes that repair this damage, ensuring the integrity of our DNA. It’s also important in cellular communication since it regulates various signaling pathways that control gene expression and cellular response to stressors.

NADH

NADH is the reduced form of NAD+. This means it has gained electrons and is ready to pass them on to other molecules. Its primary function is to act as an electron carrier in cellular respiration, which is a process that converts glucose into ATP for energy production. NADH also helps produce essential molecules for the body, such as fatty acids and cholesterol.

While both NAD+ and NADH play roles in energy metabolism, their functions differ slightly. NAD+ primarily acts as an oxidizing agent, while NADH acts as a reducing agent. This means that NAD+ accepts electrons, while NADH donates them. This difference is crucial in maintaining the balance and efficiency of cellular processes.

NADP+

NADP+ is another variation of NAD+, which has an additional phosphate group. A phosphate group is a group of atoms that are important in energy transfer reactions. This extra phosphate group allows NADP+ to carry out different functions compared to NAD+. Its primary role is to provide reducing power for biosynthetic reactions, such as the production of fatty acids and cholesterol. Additionally, NADP+ also plays a role in protecting cells from oxidative stress.

NADP+ is typically synthesized before NADPH. This reaction starts with NAD+ from either the de-novo or salvage pathway, where an enzyme called NAD+ kinase adds a phosphate group to produce NADP+.

NADPH

NADPH is the reduced form of NADP+ and is involved in many anabolic (building) reactions within cells. NADPH is essential for various biosynthetic reactions, including those in the Calvin cycle where it acts as a reducing agent to help convert carbon dioxide into glucose. It also serves a critical role in non-photosynthetic pathways by accepting electrons to reduce nitrate into ammonia for plant assimilation in the nitrogen cycle. Additionally, NADPH is involved in the production of oils and other important molecules for the body.

Benefits Of Nicotinamide Adenine Dinucleotide

Because of how NAD is involved in many cellular processes, it has been gaining attention for its potential health benefits as a supplement. Some of these potential benefits include:

Energy Metabolism

NAD+ and NADH play crucial roles in energy production, making them essential for maintaining overall cellular health. As mentioned, NAD+ is involved in converting food (glucose) into energy (ATP). Without adequate levels of NAD+, this conversion would be less efficient, leading to decreased energy production and potentially resulting in fatigue or other health issues.

DNA Repair And Maintenance

NAD+ is important for maintaining the integrity and stability of our genetic material – DNA. It is involved in repairing damaged DNA through interactions with enzymes known as sirtuins, which help regulate gene expression and maintain genome stability. 

With age, levels of NAD+ decline, leading to an increased risk of DNA damage and mutations that can contribute to age-related diseases like cancer. By promoting DNA repair, NAD+ may help prevent or slow down the development of these diseases.

Cellular Signaling

NAD+ is involved in cellular signaling pathways, which control various processes like growth and metabolism. By regulating these pathways, NAD+ can potentially impact overall health and longevity by promoting cellular health and function. Additionally, studies have shown that NAD+ may help regulate insulin sensitivity and glucose metabolism, making it a potential factor in managing conditions like diabetes.

Relationship Between NAD+ Levels And Aging

Our NAD+ levels decline as we age, due to poor diet, stress, and environmental toxins. Because NAD+ is involved in many essential cellular processes, this decline can have significant consequences for our health and longevity. In fact, the decrease in NAD+ levels has been closely linked to the aging process and age-related diseases.

The connection between NAD+ levels and aging lies in its role in energy production, DNA repair, and cellular signaling. As noted earlier, NAD+ is vital for these processes, and a decline in its levels can lead to decreased energy production, impaired DNA repair, and disrupted cellular signaling. This can contribute to the development of various age-related diseases and decrease longevity.

Moreover, studies have shown that supplementing with NAD+ precursors can increase NAD+ levels and promote healthy aging by improving mitochondrial function and reducing DNA damage. This highlights the importance of maintaining adequate NAD+ levels for healthy aging and longevity.

Links Between Age-Related Conditions And Decreased NAD Levels

Several age-related factors have links to a decline in NAD levels. These include:

  • Age-related fatigue: As indicated earlier, NAD+ is crucial for energy production. With age, our cells become less efficient at producing energy, leading to increased fatigue and a decrease in overall NAD levels.
  • Genomic instability: Because of its role in DNA repair, a decrease in NAD+ levels can lead to increased DNA damage and instability. As we age, the accumulation of mutations can contribute to the development of cancer as well as various age-related diseases.
  • Metabolic dysfunction: NAD+ is involved in regulating metabolic processes, and a decrease in its levels can impair your metabolism and increase the risk of obesity, diabetes, and other metabolic diseases.
  • Neurodegenerative diseases: There is a link between decreased NAD+ levels and neurodegenerative diseases like Alzheimer’s and Parkinson’s. This could be due to the role of NAD+ in maintaining cellular health and preventing age-related damage.
  • Cardiovascular disorders: NAD+ depletion has also been associated with an increased risk of heart failure, atherosclerosis, and other cardiovascular diseases. This is because NAD+ plays a role in maintaining vascular health and regulating blood pressure. It does this by promoting the production of nitric oxide, a molecule that helps dilate blood vessels and improve blood flow.
  • Muscle atrophy: NAD+ levels decline with age, leading to decreased muscle mass and strength. This can also contribute to mobility issues and falls in older adults.
  • Cellular senescence: NAD+ has been shown to regulate the process of cellular senescence, which is linked to age-related conditions like cancer and Alzheimer’s. A decline in NAD+ levels can potentially accelerate this process.
  • Inflammatory conditions: Inflammation is a natural response to injury and infection, but chronic inflammation can contribute to the development of age-related diseases. NAD+ has anti-inflammatory effects, and a decrease in its levels can lead to increased inflammation.
  • Insulin sensitivity: NAD+ has been shown to improve insulin sensitivity and reduce the risk of age-related conditions like diabetes. A decrease in its levels could contribute to insulin resistance as well as an increased risk of metabolic diseases.
  • Mitochondrial dysfunction: NAD+ is essential for mitochondrial function. As a result, a decline in NAD levels can lead to impaired energy production and damage to cells. This can contribute to age-related diseases like Parkinson’s and Huntington’s.

Understanding these links between NAD+ depletion and age-related conditions can help identify potential interventions or lifestyle modifications to maintain adequate NAD+ levels and promote healthy aging.

Ways To Boost NAD In The Body

Because NAD+ depletion is associated with various age-related conditions, finding ways to boost its levels in the body can have significant health benefits. Some ways to do so are through the following:

Foods Containing NAD Precursors

Certain foods contain NAD precursor molecules, such as tryptophan and niacin, which can be converted into NAD+ in the body. Precursor molecules are substances that can be converted into the desired molecule in the body. For instance, tryptophan is an amino acid that is found in foods like turkey and eggs, which can be converted into niacin, a vitamin that is essential for NAD+ production.

Other foods that contain NAD precursors include milk, yeast, and green vegetables like asparagus and broccoli. By adding these foods to your normal diet, you can support NAD+ production and maintain adequate levels in the body.

Intermittent Fasting And Caloric Restriction

Studies have shown that intermittent fasting and caloric restriction can increase NAD+ levels in the body. Intermittent fasting is the practice of alternating between periods of eating and fasting, while caloric restriction involves reducing daily calorie intake. It is believed that the body responds to periods of fasting or caloric restriction by increasing NAD+ production to support energy production and cellular repair processes.

Exercise

Regular exercise has been linked to increased NAD+ levels in the body. Exercise requires energy; therefore, the body increases NAD+ production to support the increased demand. Additionally, exercise has been shown to stimulate mitochondrial biogenesis (the creation of new mitochondria). This process also relies on NAD+ levels and can contribute to maintaining healthy cellular function.

Sun Exposure

Sun exposure, specifically UV radiation, has been shown to increase NAD+ levels in the skin. How? The skin contains a precursor molecule called nicotinamide mononucleotide (NMN) that can be converted into NAD+ when exposed to UV radiation. This is one of the reasons why sunlight exposure is essential for maintaining vitamin D levels in the body, as vitamin D is also involved in NAD+ production.

Stress Reduction

Stress hormones, such as cortisol, can inhibit NAD+ production and lead to a decrease in its levels. Therefore, finding ways to manage stress can indirectly support NAD+ production and maintain adequate levels in the body. For instance, managing stress through relaxation techniques like meditation and yoga can help support NAD+ production and maintain healthy levels.

NAD+ Supplements

Lastly, taking NAD+ supplements can directly increase NAD+ levels in the body. These supplements often contain precursors like nicotinamide riboside or niacinamide, which can be converted into NAD+. However, you should consult a healthcare provider before starting any supplement regimen.

Experience The Difference With RELATYV NAD+

At RELATYV, we offer a variety of supplements designed to support healthy aging, including our flagship product RELATYV NAD+ Sublingual S 10 and Oublingual. This unique blend is formulated to provide a synergistic effect, increasing the benefits of NAD+ supplementation. Here’s how:

  • Sublingual administration: Our NAD+ supplements come in sublingual form, which means they are placed under the tongue for faster absorption into the bloodstream. This allows for better and quicker results compared to traditional oral supplements.
  • Combined ingredients: Our supplement also contains other ingredients that are essential for NAD+ production and overall cellular health. This combination of ingredients creates a powerful formula to support healthy aging.
  • Quality guaranteed: At RELATYV, we prioritize the quality and purity of our supplements. All our products are produced in FDA-registered facilities and undergo rigorous testing to ensure both the safety and efficacy of our supplements.

With RELATYV NAD+ Sublingual S 10 and Oublingual, you can experience the difference in boosting your NAD+ levels and supporting healthy aging. The following are some potential benefits of using RELATYV NAD+ supplements:

Slows Down Aging

NAD+ is critical for maintaining cellular health and repairing damage, which can slow down the aging process. By boosting NAD+ levels, RELATYV supplements may help promote healthy aging while also reducing the risk of age-related diseases.

Boosts Cognitive And Cardiovascular Functions

Increased NAD+ levels could improve cognitive function and cardiovascular health by supporting healthy brain and heart cells. Our RELATYV supplements may help promote overall well-being by supporting these vital functions.

Reduces Inflammation

NAD+ has anti-inflammatory and antioxidant effects, which can help reduce inflammation and oxidative stress in the body. This can have a positive impact on various age-related conditions.

Increases Energy Levels

As NAD+ is essential for energy production, boosting its levels in the body can lead to increased energy and vitality, thereby helping to combat fatigue and promote a more active lifestyle.

Potential Reversal Of Metabolic Disorder Symptoms

Studies have shown that NAD+ supplementation can reverse symptoms of metabolic disorders like diabetes and fatty liver disease. This may be due to the improvements in insulin sensitivity and mitochondrial function brought about by increased NAD+ levels.

Optimize NAD Benefits Through a Reliable Source

Including NAD+ boosting practices and supplements in your daily routine can have significant health benefits, especially for aging individuals. By understanding the role of NAD+ in maintaining cellular health and identifying ways to boost its levels, you can promote healthy aging and reduce the risk of age-related diseases. 

With our RELATYV NAD+ supplements, you can experience the positive effects of optimized NAD+ levels and support your overall well-being. Consult with your healthcare provider to see if they are right for you.

Platelet-Rich Plasma (PRP) for Foot and Ankle Ligament Tears

Your foot and ankle ligaments play a vital role in enabling everyday movements such as walking, running, jumping, or climbing stairs – but they are not entirely immune to injuries such as tears and sprains. 

Today, it is estimated that nearly 40% of adults will suffer from foot pain at least once in their lives, and acute ankle sprains account for approximately 20% of all injury-related emergency department visits. Despite how common and impactful these musculoskeletal problems are, the common lines of treatment prescribed – such as painkillers and corticosteroid injections – are still inefficient in treating the root cause of pain and inflammation.  

Fortunately, you no longer need to endure the side effects of medications or resort to surgery to regain your foot and ankle function. Thanks to the superior Platelet-Rich Plasma injections offered at Orthagenex, you can support your body’s self-healing capabilities and get back on your feet. Here’s all you need to know.

Foot and Ankle Ligament Tears – Overview

Ligaments are strong bands of connective tissues that link one bone to another. They are responsible for keeping your joints stable, controlling movement, and preventing injuries such as dislocations. 

Each foot has over 30 ligaments. These resilient “ropes” stabilize the gait, redistribute your body weight as you walk, provide support to the arch of the foot, and act as powerful shock absorbers. 

The ligaments in the foot and ankle – which include the plantar fascia, the calcaneocuboid ligament, and the lisfranc ligament – run along the arch of the foot, across its width, and over the heel. This structure connects the different structures of the foot, such as the heel, ankle joint, toes, and sole.

Arthritis at ankle joint (Gout , Rheumatoid arthritis)

Several factors, such as direct trauma, overuse, and non-contact injuries, can cause these ligaments to stretch beyond capacity, extend in the wrong direction, or wear down. This can lead to tears, sprains, or, in severe cases, ruptures (which occur when the ligament is completely detached from the bone). 

Causes of foot and ankle ligament tears include:

  • Direct blows and traumatic injuries that involve the ankle or foot
  • Falling or landing on your feet in an awkward position, which can lead to twisting your ankle
  • Objects or another person falling on the foot
  • Regularly running or walking on uneven surfaces (i.e.: participating in jogging or trail running)

Ligament tears are made more likely due to the degeneration that occurs normally as you age. This wear and tear can be aggravated by factors such as smoking, drinking alcohol, wearing improper footwear, or having a sedentary lifestyle. 
Additionally, due to the extra weight your body may carry, you can be at higher risk of foot ligament and tendon injuries if you are overweight or obese.

Symptoms of Foot and Ankle Ligament Tears

If you have mildly twisted your ankle, the chances are that the pain you are experiencing is nothing more than a minor, temporary issue. In these cases, you may regain your foot function through some at-home remedies and rest. 

Nonetheless, recurring or acute ligament tears should not be underestimated. According to studies, approximately 70% of acute ankle sprain cases lead to long-lasting complications such as chronic ankle instability (CAI), chronic pain, and reduced mobility. 

Ligament tears are categorized into three grades of severity:

  • Grade I – Light stretching of the ligament that causes a very mild tear
  • Grade II – A more serious but incomplete tear that can cause some ankle instability
  • Grade III – A completely torn (ruptured) ligament, which causes significant instability.

Ankle ligament tears can occur due to different movements, which will determine the location of the symptoms:

  • Inversion, or rolling your ankle inwards
  • Eversion, or rolling your ankle outward
  • High ankle sprain, which occurs when the foot is stretched upwards (toward the shin) beyond capacity

Depending on the nature and severity of your ligament tear, you are likely to experience the following symptoms: 

  • A “popping” sound, usually accompanied by acute pain, at the time of injury
  • Pain that spreads around the ankle and across the lower leg area
  • Pain that intensifies during movement or after periods of rest 
  • Swelling, stiffness, and a sensation of warmth, which are consequences of the inflammatory response
  • Bruising 
  • Ankle weakness
  • Joint instability and difficulty in load-bearing
  • Having trouble walking 
  • Reduced range of motion 

If the tears are associated with improper foot mechanics, you may also suffer other complications, such as abnormal bony growth. These occur when the body attempts to repair tissues damaged by inflammation and overuse by growing new bone tissue.

Conventional Treatment Options

Foot ligament sprains are, in some cases, a minor problem that will resolve on its own in just a few days or weeks. For a mild tear, techniques such as RICE (Rest, Ice, Compression, and Elevation) can help decrease swelling and inflammation, thus improving foot and ankle function. 

However, if you’ve suffered an acute tear or you are experiencing chronic foot pain and dysfunction, your doctor may prescribe one of the conventional treatment options available: NSAIDs, corticosteroid injections, or surgery. 

These lines of treatment do very little to tackle the root cause of your foot condition, and they may expose you to significant risks and side effects. Let’s look at these options in more detail below.

Corticosteroid Injections

Corticosteroids work by mimicking the action of cortisol, a hormone produced naturally by your body, which is responsible for regulating inflammation and pain perception.

Typically, corticosteroids are injected directly into the area causing discomfort (the ankle or foot, in this case). Once injected, the crystals contained in the formulation gradually release pain-killing substances, which lead to a more sustained analgesic effect compared to other pain medications. 

Despite their widespread usage in treating various types of pain, corticosteroids may not always be the most suitable or safest treatment option available. Long-term usage of corticosteroids can interfere with your adrenal glands – the cortisol-producing powerhouses of your body – and even lead to cartilage breakdown. 

NSAIDs

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed medications during emergency department visits for ankle and foot ligament tears.

These medications work by inhibiting the COX (cyclooxygenase) enzyme, which plays a crucial role in producing prostaglandins. These are essentially chemicals that trigger inflammation within your body. Lower prostaglandin production equals lessened inflammation and pain – temporarily, at least. 
While these medications are affordable and accessible as an over-the-counter solution, their consumption should not be taken lightly. Indeed, long-term use of NSAIDs has been seen to be associated with side effects such as stomach ulcers, kidney dysfunction, risk of addiction, and higher likelihood of heart attack and stroke.

Arthroscopy

If you are suffering from serious ligament tears or rupture, your doctor may suggest one of two surgeries: arthroscopy or open ligament reconstruction surgery. 

Arthroscopy is a minimally invasive strategy, offering surgeons a clear view of the joint’s inner structures. This is achieved by making a small cut and inserting a tiny camera attached to a narrow, flexible tube. The viewing instrument can be used to diagnose the extent of the damage, as well as to guide surgical techniques to alleviate ligament pressure and remove any debris causing discomfort and inflammation.

However, while arthroscopy is less invasive than other methods, it’s not devoid of risk. For example, there could be negative reactions to anesthesia, infection risks, and less effective outcomes.

Ligament Reconstruction Surgery 

If your ligaments are severely damaged, your physician might suggest a reconstruction. This procedure can follow two methods: Brostrom-Gould or tendon transfer. 

In the Brostrom-Gould method, surgeons stabilize the ligaments using stitches. On the other hand, tendon transfer replaces the damaged ligament with tissue from a healthy tendon. This replacement could be harvested from elsewhere in your body or from a donor, and, during the operation, it is securely fastened using stitches, screws, and pins.

Before opting for ligament reconstruction surgery, it’s crucial to weigh its risks. Complications can include infection, bleeding, or nerve damage during surgery, or even problems with the healing process post-operation. Moreover, the transplanted tendon might not integrate well into your foot or ankle, leading to limited mobility or potential future injuries.

Even in the best-case scenarios, invasive procedures come with lengthy recovery and rehabilitation periods.

What is Platelet-Rich Plasma, or PRP? 

PRP – which stands for Platelet-Rich Plasma – is a form of regenerative therapy that uses the patient’s own blood. After being collected, these blood samples are concentrated to offer far higher concentrations of platelets than baseline values. 

Platelets are the component of the blood responsible for enabling healing processes such as blood clotting. To add to the healing potential of platelets is the fact that they are extraordinarily rich in growth factors

Found within platelets in “pockets” known as alpha granulate, growth factors are proteins capable of stimulating the activity of stem cells within the site of injury. What’s more, these proteins are able to activate the transformation process of adult stem cells into other cells needed to replace and regenerate damaged tissues.  

They can also “call to action” repair cells from across the body to the injured site. 

Being rich in platelets, PRP offers a simple, safe, and effective way of delivering growth factors to the area in need. Acting as “espresso shots”, these growth factors will stimulate the body’s ability to heal damaged tissues – such as torn ankle and foot ligaments.

PRP for Foot and Ankle Ligament Tears 

The capacity of Platelet Rich Plasma (PRP) to boost your body’s natural healing abilities makes it an integral component of regenerative therapies. Regenerative orthopedics, for example, utilizes PRP to effectively address conditions like joint instability, arthritis, muscle strains, and tears in ligaments and tendons.

Up to this point, more than 30 randomized trials have demonstrated how PRP can stimulate the healing abilities of stem cells at injury sites. Given the safety level of PRP injections and their efficiency in boosting the body’s self-healing capabilities, this is now considered a superior alternative to treatment options such as corticosteroids and pain medications. 

Specifically, in the treatment of foot and ankle ligament tears, studies have confirmed the potential of PRP. Here’s an overview of current research:

  • Although there are several factors influencing the outcomes of PRP, this therapy can be used in the treatment of connective tissue injuries (i.e.: ligament and tendon tears), and it can aid the recovery process. (2014)
  • PRP can significantly reduce the pain associated with ankle sprains, and lead to better clinical results than other treatment options. (2022)
  • Patients with a lateral ankle sprain treated with PRP achieved a higher reduction in pain and better functional scores than patients treated with immobilization 8 weeks following the injection. (2020)
  • A single PRP injection contributed to the quick and safe return to play of Rugby Union athletes suffering from chronic ankle ligament conditions. (2015)

Why are Orthagenex PRP Injections Superior?

The studies reported above show that Platelet Rich Plasma has the potential to be a far safer and more efficient alternative to painkillers, corticosteroid injections, and surgery for the treatment of foot and ankle ligament tears. 

Nonetheless, not all PRP therapies advertised on the market are equally efficient – nor do they lead to the same results. So, what makes the solutions offered at Orthagenex superior?

There are four main features that take the Orthagenex PRP protocol to the next level:

  • The use of image guidance to accurately deliver PRP injections to the site of injury
  • Lab-processed solutions to boost the concentrations of platelets and reduce unfavorable components
  • Ad hoc injectates that are customized around the unique needs and health goals of each patient
  • Doctors who are highly trained in Interventional Orthopedics

The combination of these features allows Orthagenex to offer a superior form of PRP – a high-dose PRP.

Below, we’ll look in detail at each of these features and discover how our core competencies help us achieve better health outcomes. 

Interventional Orthopedics

Orthagenex’s cutting-edge protocols have pioneered the development of a new, recognized medical specialty: interventional orthopedics. This field is based on three pillars: 

  1. The use of injections, like PRP, to promote tissue regeneration and support the body’s own healing capabilities.
  2. The use of imaging guidance to boost precision in needle positioning
  3. The continuous improvement of injection solutions and delivery techniques that can lead to better health outcomes.

Image-Guidance to Place PRP Solutions

Imaging guidance refers to all of those techniques and tools used to reduce reliance on tactile sensations while delivering injections to the site of injury. These techniques allow the physician performing the injection to maintain real-time visuals of the needle from the moment it enters the skin onward. 

Currently, as standard procedure, US clinics offering PRP do not use imaging guidance. This can lead to a higher rate of mispositioning of the needle, thus causing surgeons to miss the target location of PRP injections. Even in those cases when imaging guidance is used, physicians usually don’t have the knowledge and training necessary to accurately interpret results. 

That’s where Orthagenex sets itself apart. At our clinics, imaging guidance is used throughout each PRP injection as part of our standard protocol. To achieve greater precision, we take advantage of two of the most advanced imaging guidance techniques available:

  • Ultrasound guidance, which uses ultrasound waves to offer real-time position data of the needle as it enters the skin
  • Fluoroscopy, which offers real-time, multi-angle X-ray images of the needle’s positioning as it targets the site of injury.

Not only are these techniques used in combination, but they are also delivered by a team of specialized technicians trained to accurately interpret results.

Lab-Processed for Higher Concentrations of Platelets

Besides the accuracy of needle positioning, the efficacy of PRP therapies in boosting the body’s ability to heal damaged tissues is also determined by two factors: the concentration of platelets and the purity of the injectates.

However, the tools and techniques used by most clinics offering PRP in the use aren’t powerful enough to create super-concentrated, pure injections. This is because, in most cases, standard bedside centrifuges are used. 

These centrifuges work by spinning the blood sample and separating the different components of the blood. They are not, however, efficient in optimizing the concentrations of platelets – nor in removing unfavorable components (i.e.: white and red blood cells). What makes these injections even less efficient is the fact that they are immediately delivered to the site of injury after processing, without further customization processes. 

To offer superior High-Dose PRP, Orthagenex employs in-house laboratories. After collection, blood samples are delivered to our cellular labs, where they are processed using cutting-edge techniques. These processes help guarantee optimal platelet volumes, as well as purer and entirely customized injections. 

The chart below offers an overview of the differences between Orthagenex’s protocols and the techniques used by most other orthopedic clinics in the nation. 

Other clinicsOrthagenex
Tools used to create PRPBedside centrifuges, usually located on the patient’s bedside. Specialized laboratories equipped with cutting-edge equipment
Protocol to perform PRPAfter being centrifuged, PRP is immediately injected into the site of the injury The blood sample is concentrated, purified, and customized before injection. 
Resulting concentration of platelets in PRPMaximum 2-4 times higher than “normal blood” values 10-30 times higher than “normal blood” values. 

Amber PRP vs. Red PRP

Platelet Rich Plasma comes in two forms, which can be distinguished by their color:

  • Red PRP: This solution appears red, due to the high presence of both white and red blood cells along with platelets. The medical term for this is Leukocyte-Rich PRP or LR-PRP. 
  • Amber PRP: This type of PRP has a distinct amber color due to the lower concentration of white and red blood cells. It is referred to medically as Leukocyte-Poor PRP or LP-PRP.

In essence, the color difference is determined by the presence specific blood cells. According to the lab tests conducted at Orthagenex, these blood cells can have an unfavorable effect on PRP outcomes. Simply, red and white blood cells can contribute to inflammation at the site of injury, and they may have an inhibiting effect on the repair cells that PRP is attempting to stimulate. 

Amber PRP is purer, less inflammatory, and offers higher concentrations of platelets. These features make Amber LP-PRP the solution of choice at Orthagenex

Next-Generation Platelet Lysate 

Just like Platelet Rich Plasma (PRP), Platelet Lysate (PL) enhances the action of repair cells at the site of injury thanks to optimized concentrations of platelets and growth factors. 

However, some characteristics of PL make it a better alternative in some cases. Firstly PL is remarkably anti-inflammatory. Additionally, these injections release growth factors en-masse to the site of injury, thus leading to faster results. 

The chart below offers an overview of the two therapies offered at Orthagenex. 

PRPPL
Releases platelets and growth factors over time to the site of the injury, usually over a week.Growth factors are released immediately, en masse, to the site of the injury. 
May cause some degree of inflammation upon injection.It is anti-inflammatory. 
May not be as suitable for treating sensitive areas. It can be used around sensitive areas (e.g. near nerves and the spinal cord).

While most clinics across the US are just beginning to offer Platelet Lysate to their patients, Orthagenex is now making the third and fourth generations of PL injections available as part of our standard treatments. Our main focus remains on continuously developing better, more efficient PL injectates. 

PRP Customized To Every Patient’s Need

Besides the high concentrations of platelets, what makes our high-dose PRP protocol superior is the level of customization we offer to each patient

At Orthagenex, we understand that foot and ankle ligament tears are complex disorders that can manifest themselves with a variety of symptoms and impacts. Because of this, we leverage specialized in-house cellular laboratories to tailor each injection to the patient’s needs and desired health outcomes. 

Here’s an overview of our customization process: 

Lab-Processed PRP Solutions

At Orthagenex, we believe in going beyond conventional practices. Instead of using basic centrifuge machines, we take advantage of cutting-edge cellular lab environments. Here, our highly trained specialists use state-of-the-art equipment to tailor each injection for optimized health outcomes. 

Each formulation is created ad hoc, and it undergoes several stages of processing to ensure greater concentrations of platelets, higher levels of purity, and fine-tuned components. 

Bone Marrow Concentrate Can Be Used 

Bone marrow concentrate (BMC) works alongside PRP as an additional regenerative therapy. BMC’s primary aim is to boost the levels of restorative repair cells in the areas of the body (such as the ankle and foot) that have suffered injuries, degeneration, pain, and inflammation.

In BMC, samples of the liquid part of the bone marrow are collected by creating a thin tunnel into the bone, usually near the pelvis. This bone marrow, which is extraordinarily rich in stem cells, is then concentrated and purified, before being re-injected into the site of injury. Here, the injectate replenishes the levels of stem cells and optimizes the body’s ability to heal naturally. 

Doctors Specializing in Interventional Orthopedics

If, at Orthagenex, we are able to offer superior Platelet-Rich Plasma therapies it is thanks to our team of highly trained technicians and doctors. 

Each member of our team is a specialist in musculoskeletal disciplines, board-certified, and fellowship-trained. Our doctors are also among the 1% of physicians in the US who are trained in Interventional Orthopedics and imaging guidance. These numbers alone show how Orthagenex has been able to help more orthopedic patients than any other regenerative medicine clinic in the nation. 

Core Competencies

  • The use of imaging guidance to boost needle placement accuracy
  • Lab-processed solutions for higher concentrations of platelets
  • Formulations entirely customized to each patient’s needs
  • The use of the purer Amber LP-PRP injections
  • The availability of supplementary regenerative therapies, such as lysate (PL) and bone marrow concentrate (BMC)
  • The use of SANS – our proprietary method of evaluation for systemic inflammation and chronic pain conditions. 

Most chronic pain conditions deriving from systemic inflammation are non-specific, meaning that they can result from a wide range of causes and risk factors (including lifestyle and environmental factors). Without having a clear understanding of what’s causing a patient’s chronic pain, it can be hard for doctors to perform an accurate diagnosis and decide on a safe and efficient form of treatment. 

That’s where SANS comes in. SANS stands for Stability, Articulation, Neuromuscular, and Symmetry. Analyzing these aspects of chronic pain conditions allows our physicians to more accurately determine the extent, nature, location, and cause of chronic pain and inflammation. This knowledge can then help guide treatment decisions. 

Orthagenex – Your Alternative to Foot and Ankle Ligament Tears Surgery

Mild ankle sprains are something we have all experienced at least once in our lives. And, in most cases, they are nothing more than a temporary condition that can be resolved with at-home remedies. 

However, in some cases, ankle and foot ligament tears can be acute or chronic, which can lead to long-lasting instability, reduced range of motion, and inhibited performance. When this happens, you may be recommended one of three, equally undesirable lines of treatment: NSAIDs, corticosteroid injections, or surgery. 
Nonetheless, there is no longer reason to endure the risks and side effects of these treatment options. The superior Platelet Rich Plasma injections offered at Orthaganex may help you regain your foot function and health by boosting your body’s natural ability to heal itself – without medications or surgery.

High-Dose PRP For Spinal Stenosis

Spinal stenosis can be an incredibly debilitating condition as it can cause chronic pain and a lack of mobility in the back, hips, and legs. As a result, the condition can significantly diminish your quality of life if not properly treated. Unfortunately, spinal stenosis can not be cured since it’s caused by degenerative changes in the spine. However, there are ways to treat spinal stenosis so that you can manage the symptoms and improve your quality of life. One of the most effective treatments is high-dose platelet-rich plasma (PRP) injections.

Understanding The Spinal Stenosis Condition 

Spinal stenosis develops when the spinal canal becomes too narrow, thereby compressing the nerves. Nerve compression, in turn, can affect movement and sensation. This narrowing of the spinal canal can be caused by age-related degeneration or injury.

Oftentimes, there is no pain or discomfort until the narrowing worsens and compresses the nerve roots. Patients may experience various symptoms when this happens, including lower back pain, numbness, tingling, and weakness in the extremities. In more severe cases, patients may experience a loss of bladder or bowel control.

Spinal stenosis can cause so many different symptoms because the spine is essentially the highway for the central nervous system. Excessive pressure on the nerves that make up this “highway” can have far-reaching effects throughout the body.

The Difficulty Of Diagnosing Spinal Stenosis

It’s estimated that anywhere between 250,000 to 500,000 Americans are living with symptoms caused by spinal stenosis. It’s a much more common condition in older patients because it’s often caused by age-related degeneration. Studies show that roughly five out of every 1000 persons over 50 are likely to have the condition. However, the exact prevalence is difficult to determine because spinal stenosis can be hard to diagnose. 

One significant difficulty in diagnosing spinal stenosis is that the symptoms can be similar to other conditions, such as herniated discs or scoliosis. Additionally, because spinal stenosis can cause pain in other areas of the body (such as in the leg or hip), the condition can be easily misdiagnosed. Finally, many people with spinal stenosis don’t show any symptoms until the narrowing of the spine is quite severe and is pressing on the nerves. As a result, it can be difficult to identify the condition until it has progressed significantly.

Why Seek Out High-Dose PRP Injections For Spinal Stenosis? 

Conservative treatments for spinal stenosis include anti-inflammatories and epidural cortisone injections. The problem with these types of treatments is that they only provide temporary relief by masking the symptoms and do not address the condition’s underlying cause.

In more severe cases, a traditional doctor might suggest a surgical procedure, such as a laminectomy, which involves cutting away bone and tissue to reduce pressure on the nerves. The problem with such procedures is that not only can they be expensive, but they are incredibly invasive. Because of this, there are potential complications, including infections, allergic reactions, long recovery times, and the potential for nerve damage.

How PRP Injections Work 

Platelet-rich plasma is a concentration of platelets from the patient’s blood. This plasma is rich in growth factors that aid in healing and promote tissue regeneration. When administered directly to the affected area, these growth factors can help stimulate and accelerate tissue repair.

When treating spinal stenosis, injections of high doses of platelet-rich plasma can help reduce swelling and inflammation in the spine by promoting tissue regeneration in the affected area. As a result, PRP injections help alleviate pressure on the nerves, which can help provide long-term relief from pain, numbness, and other symptoms caused by spinal stenosis.

The Basic Procedures Of PRP Treatment

The procedure for treating spinal stenosis with PRP injections is relatively straightforward. First, the doctor will draw the patient’s blood, and the platelet-rich plasma will be extracted from it. The site where the injection will be administered is then treated with a numbing agent. Once this agent takes effect, the PRP is injected with a needle. The doctor administering the injection will use ultrasound imaging as a guide to ensure that the injection is accurate and effective. 

Drawing the blood and processing the platelets will take roughly 30 minutes. Then, it will take another 15 minutes or so for the numbing agent to take effect. Finally, the actual injection shouldn’t take more than 10 to 30 minutes. All in all, you can expect the entire procedure to take an hour to an hour and a half.

Patients may experience some mild discomfort or soreness in the area of the injection, but this should fade quickly. In most cases, patients experience a significant reduction in pain and other symptoms within just a few days. However, several injections may be needed depending on the severity of the condition and individual circumstances. Typically, you’ll need to undergo anywhere from two to six injections one to two weeks apart.

How Safe Are PRP Injections?

PRP injections are generally considered safe, with few risks and side effects. While there is always a risk of infection associated with any injection, the risk is minimal when using a sterile procedure and medical-grade equipment. Additionally, some patients may experience mild discomfort or soreness at the injection site. However, this should resolve quickly. You may experience some swelling and bruising as well, both of which should subside after a few days.

The primary benefit of using PRP injections for treatment is that it is an effective and minimally invasive method of treating spinal stenosis. It also carries fewer risks than surgery, as well as a shorter recovery time and less disruption to the patient’s daily activities. Not to mention, the substance being injected is the patient’s own platelet-rich plasma, so there is no risk of an allergic reaction, nor are there any risks of side effects similar to those presented when using anti-inflammatory drugs or corticosteroid injections.

Results From High-Dose PRP Treatment Of Spinal Stenosis

Recovery time following injections is quick. Any side effects (such as mild pain or bruising) should disappear after 48 hours. However, you should avoid strenuous exercises for a few weeks afterward. Most patients will begin experiencing pain relief within two to three weeks after their first injection, after which results will continue to improve for three to six months.

Studies have shown that PRP injections are highly effective at providing long-term pain relief for patients suffering from chronic back pain in general. For example, one study found that subjects treated with PRP injections experienced a significant decrease in the intensity of their pain after six months.
It’s also worth noting that according to a report published by the Journal of Spine Surgery, PRP injections had the same impact on research subjects dealing with chronic pain caused by disc degeneration (meaning, subjects experienced a significant amount of pain relief after six months). Because of how PRP injections work, their success in managing pain caused by disc degeneration also applies to how they can treat spinal stenosis.

Targeting Spinal Stenosis Pain At The Source

High-dose PRP injections are a safe, minimally-invasive, drug-free alternative for treating spinal stenosis. At Orthagenex, we offer the highest quality and safest PRP treatments to help provide optimal outcomes for our patients. We develop personalized treatment plans tailored to each individual’s condition and needs. We are committed to providing the best possible care for those suffering from chronic spinal stenosis pain. Contact us for more information on how PRP injections can help you find relief from chronic pain and improve your quality of life.

Understanding High-Dose PRP Treatment For Sports Injuries

Anyone who has played sports their whole life has likely experienced an injury or two at some point, whether it’s a twisted ankle or a strained muscle. Some injuries may go away on their own after a few weeks of rest. Unfortunately, other types of injuries, such as a ligament or tendon strain, a muscle tear, or cartilage damage, can put you out of commission for a long period of time. In fact, sports-related injuries like these can take a long time to heal if untreated and can be very painful. High-dose PRP (platelet-rich plasma) treatment is effective for these and other sports injuries.

Why You Shouldn’t Ignore Sports Injuries

Sports-related injuries can lead to serious long-term damage if left untreated. Not only can sports injuries cause pain and reduce your range of motion, but they can also lead to chronic inflammation, which can further damage tissue. Therefore, it is essential to seek help as soon as possible to properly treat and heal the injury to prevent long-term problems from developing.

How Past Injuries Can Affect Your Present-Day Life

Even if you experienced an injury years ago, it may cause ongoing trauma in different parts of the body. For example, a ligament tear may cause instability in the knee joint, leading to chronic pain and discomfort later in life. In addition, the injury may cause muscle weakness and can result in the inability to perform certain activities, such as running or jumping. This means that if you’re experiencing chronic pain today, it could be the result of a sports-related injury you had years ago.

Why Consider High-Dose Platelet-Rich Plasma (PRP) Injection As A Treatment

Recent developments in the field of high-dose PRP injection have made it an increasingly popular option for treating sports injuries and other musculoskeletal conditions. Research has found that this treatment can effectively promote tissue repair, reduce inflammation, and increase range of motion. 
Additionally, the treatments are safe and effective with minimal side effects. One particular study found that 83.3 percent of subjects undergoing PRP treatments for sports-related injuries were able to return to normal daily physical activity and to playing sports. Additionally, another study concluded that PRP treatments were optimal for sports-related injuries that were not responding to conservative management.

Benefits Of High Dose PRP Treatment

High-dose PRP treatments have been shown to provide significant pain relief and improved mobility in patients with sports-related injuries. These treatments also promote tissue healing and regeneration, reducing the risk of further damage. Additionally, the following benefits can be expected from high-dose PRP treatments:

  • Safe: High-dose PRP treatments are safe and rarely cause adverse effects. This is because the substance being injected is derived from the patient’s own blood, so it won’t cause an adverse reaction.
  • Minimally Invasive: The PRP procedure is minimally invasive and does not require surgery or long-term recovery. The treatment can be completed in one visit, and side effects are rare. If they do occur, they are minor.
  • Fast Recovery Time: Because of how minimally invasive the procedure is, recovery times tend to be fast, and patients can often resume regular activities soon after treatment.
  • Treats Pain At The Source: High-dose PRP treatments target the source of the pain, rather than just masking it. They do this by promoting tissue healing and regeneration

How High-Dose PRP Works For Sports Injuries

High-dose PRP treatments involve injecting concentrated amounts of platelets into the injured area. Platelets are tiny cells found in the blood that contain a variety of growth factors and proteins that can trigger the body’s natural healing process. These growth factors help reduce inflammation, promote tissue regeneration and repair, and stimulate new blood vessel growth, which helps to deliver essential nutrients to the injured area. 

High doses of PRP are ideal for treating sports injuries, as they can help to reduce pain and inflammation more quickly than lower doses. Additionally, high doses can help promote healthy tissue growth and reduce the risk of further damage. As a result, patients who receive high-dose PRP treatments often experience faster recovery times and improved mobility.

Sports Injuries That Respond To PRP Treatment

PRP treatment is effective for a wide range of injuries, but they are especially beneficial for those that involve soft tissue damage, which is a common result of sports-related injuries. Examples of common sports injuries that respond well to PRP treatment include:

Meniscal Tears

Meniscal tears are considered one of the most common knee injuries and can be caused by sudden twists or turns. These tears create sharp or stabbing pain in the knee joint, swelling, and stiffness. A meniscus tear can limit mobility and may even lead to arthritis in the long run if not treated properly. However, high-dose PRP treatments can help to reduce pain and inflammation and promote tissue healing in the area of the tear.

ACL Injuries

Anterior cruciate ligament (ACL) injuries are fairly common among athletes who play sports that involve quick changes of direction and jumping. ACL injuries can cause pain, swelling, and instability in the knee joint. Long-term complications can include arthritis and further damage to the joint. PRP injections have been found to reduce pain and inflammation caused by ACL injuries, as well as strengthen ligaments and improve stability.

Tennis Elbow

Tennis elbow is a common condition affecting the elbow and forearm tendons. As the name indicates, it is most often seen in tennis players, but can also affect athletes of other sports, such as golf. Tennis elbow can cause pain and tenderness on the outside of the arm, as well as a decreased grip strength. PRP treatments for tennis elbow have been found to reduce pain and inflammation and improve grip strength.

Jumper’s Knee

Jumper’s knee, or patellar tendonitis, is a condition that affects the tendons around the kneecap. More specifically, it is caused by irritation, inflammation, and small tears in the patellar tendon. It can cause pain, swelling, and decreased range of motion in the knee joint. If you play sports involving jumping, such as basketball or volleyball, then you’re more likely to suffer from this condition. It can cause pain and tenderness on the front of the knee, as well as swelling and decreased flexibility and mobility. PRP treatments can help reduce pain and inflammation caused by jumper’s knee and promote tissue healing.

Rotator Cuff Injuries

Rotator cuff injuries are common among athletes in contact sports, such as football and wrestling. These injuries cause pain, tenderness, and stiffness in the shoulder joint and can significantly limit mobility. In severe cases, rotator cuff injuries can even lead to full rotator cuff muscle tears, which may require surgery. PRP injections are effective in reducing pain, swelling, and inflammation. They also promote tissue healing which reduces the risk of aggravating the injury.

Plantar Fasciitis

Plantar fasciitis affects the ligaments that connect the heel bone to the toes. It causes pain and tenderness in the bottom of the foot, as well as decreased mobility. Any sport involving running or jumping can cause plantar fasciitis, as it puts tremendous stress on the feet. PRP injections have been found to reduce pain and inflammation in patients with plantar fasciitis, as well as promote tissue healing in the area. This can help to relieve pressure on the foot and improve mobility.

How Do You Know If PRP Treatment Is For You? 

PRP treatments are not just for elite athletes; they can benefit anyone who has experienced a sports injury. For example, you may have experienced a sports-related injury years ago when playing for your high school football team or while casually playing golf with your coworkers over the past weekend. Whether you’re experiencing lingering pain due to a past injury or have recently injured yourself during a recreational activity, PRP injections can help reduce pain and inflammation and promote tissue healing. 

It’s essential to remember that PRP treatments are not a guarantee of complete recovery from an injury. However, they can be beneficial for reducing pain and inflammation, as well as promoting tissue regeneration and repair. Ultimately, PRP treatments can help you get back to doing the activities you love with minimal discomfort and improved mobility without having to resort to a dependence on pain medications or an invasive (and expensive) surgical procedure.

Trust Orthagenex With Treating Your Sports Injury

At Orthagenex, we believe that high-dose PRP treatments can make a significant difference in treating and relieving pain caused by sports injuries. Our specialists have extensive experience in providing these treatments, and they use the most advanced technology to ensure the best possible results. 

If you suffered from a musculoskeletal injury caused while playing sports, contact Orthagenex today to learn more about our PRP treatment options and see how we can help you achieve long-term pain relief so you can get back to playing the sports you love as soon as possible.

High-Dose PRP for Spondylolisthesis

Platelet-rich plasma (PRP) treatment is a minimally invasive, cutting-edge therapy for treating musculoskeletal pain. It uses the body’s healing agents to reduce pain and inflammation. PRP can be used to treat a variety of issues, including those related to joints, muscles, and bones. It can also be used to treat spondylolisthesis; a condition in which one vertebra slips out of place and causes pain.

Understanding Spondylolisthesis

Spondylolisthesis is a common condition that affects between four and six percent of all children and five to 10 percent of adults, according to a study conducted by David Gendelberg, MD. The condition can cause pain in the lower back area and make it challenging to move around. The following is a breakdown of the spondylolisthesis subcategories, causes, risk factors, and symptoms:

Subcategories of Spondylolisthesis

The following are the most common types of spondylolisthesis:

  • Dysplastic: This type of spondylolisthesis is caused by an abnormality in the development of the spine joints at birth. It is usually congenital and tends to be more common in children. Because the defect can weaken the facet joints, the vertebrae are more likely to be knocked out of alignment due to everyday movements.
  • Isthmic: This type of spondylolisthesis is caused by a fracture in the pars interarticularis (a strip of bone connecting the vertebrae at the facet joints). This condition generally occurs in children between the ages of five and seven; however, it may not be diagnosed until adulthood after the joints have degenerated, resulting in spondylolisthesis. 
  • Degenerative: This type of spondylolisthesis is caused by the natural wear and tear of joints, making it a common result of osteoarthritis. It usually occurs in older individuals over 60 years old. Degenerative spondylolisthesis often results in additional symptoms, such as muscular weakness in the hamstrings.
  • Traumatic: This type of spondylolisthesis is caused by an injury or trauma to the spine. For example, if you fall down the stairs and the impact of the ground knocks your vertebrae out of alignment.
  • Pathologic: This type of spondylolisthesis is caused by a disease (such as Paget’s disease or osteomyelitis) or a tumor that weakens the points of attachment that hold together the vertebrae, making it more vulnerable to slipping out of place.

Common Causes And Risk Factors

Although one of the significant causes of spondylolisthesis is injury (it often occurs in athletes while playing physical sports), it’s important to note that the condition has a genetic component present in 15 to 69 percent of patients. In fact, many patients who believe they can trace their condition back to a traumatic injury may have a family history of the condition that could be just as likely to blame. Keeping this in mind, other risk factors for spondylolisthesis include the following:

  • Injuries and trauma from accidents
  • Abnormal wear and tear on the spinal bones
  • Additional stress from sports and other strenuous activities
  • Concurrent conditions such as arthritis and bone disease
  • Prior damage from fractures, tumors, or bone abnormalities

Common Symptoms

Not everybody with spondylolisthesis will experience symptoms; in fact, many people go years without being diagnosed with the condition because they never experienced symptoms. With that in mind, the following are some of the most common symptoms associated with spondylolisthesis:

  • Lower back pain
  • Muscle tightness
  • Pain and numbness in the thighs or buttocks
  • Tenderness in the area of the dislocated vertebra
  • Weakness in the legs
  • Stiffness
  • Changes in posture and gait

Why Treatment Matters

If left untreated, spondylolisthesis can cause many issues that affect more than just back pain. Due to the misalignment of the spine, it can put pressure on nerves and cause neurological conditions, meaning the nerves don’t transmit properly. This can cause numbness, tingling, and weakness throughout the body– including in the legs and feet.

 Furthermore, untreated spondylolisthesis can cause a person to lose their balance more easily and have difficulty walking. It can also lead to a decrease in bladder control. All of these issues can seriously impact your quality of life, making it vital to seek treatment as soon as possible.

PRP Injection For Spondylolisthesis: An Alternative To Surgery

Platelet-rich plasma (PRP) injections are a promising alternative to traditional surgery to treat spondylolisthesis. However, surgical procedures to correct the condition are often invasive and can cause additional damage to surrounding tissues. They’re incredibly risky because the spine needs to be manipulated for the vertebrae to be corrected. Not to mention that there’s always the risk of complications, such as infections, when it comes to surgery. Surgical procedures can result in long recovery times, can be incredibly expensive, and aren’t guaranteed success.

On the other hand, PRP injections are a minimally invasive procedure that can be used to treat spondylolisthesis and other back conditions. A high dose of PRP is injected directly into the affected area, which helps to promote the natural healing process.

How PRP Works

PRP is made from a sample of the patient’s own blood. It contains growth factors, proteins, and other substances that can promote healing and reduce inflammation. When PRP is injected into an area of tissue damage or injury, it triggers a cascade of repair processes in the body.

When treating spondylolisthesis, a higher dose of PRP is ideal because it contains a greater concentration of growth factors and proteins. This helps stimulate the body’s healing process while reducing inflammation around the area of injury. This increased dosage is also more likely to promote a longer-term solution as opposed to short-term relief of symptoms.

What The Research Says

Numerous studies have been done to research the effectiveness of high-dose PRP treatments as an alternative to surgery for treating spondylolisthesis. One recent study conducted in 2022 and led by Dr. Dalia Saif involved comparing a group of 100 patients with grade-1 degenerative spondylolisthesis. Half of the group underwent surgery, while the other half underwent three high-dose PRP injections into their facet-joint capsules. Both groups of patients were found to have improvements in pain and function. Those who underwent surgery have sustained results for nine months of the study period. In contrast, those who underwent PRP treatment sustained results for 12 months.

Not only did the PRP treatment yield effective results that lasted longer, but when comparing three injections to an invasive surgical procedure, PRP is a much safer and more convenient alternative.

What To Expect From High-Dose PRP Treatment

Depending on the diagnosis and the severity of the condition, a patient may need to undergo several PRP injections. Generally speaking, two to six injections are recommended, spaced one to two weeks apart. The following are the things you can expect during each part of the PRP treatment process:

  • Preparation: Once you’ve scheduled your appointment, you’ll need to refrain from taking nonsteroidal anti-inflammatory drugs (NSAIDs) for at least two weeks before your PRP treatment. These NSAIDS include ibuprofen and aspirin. This can be difficult to do, especially if you take these medications as pain relief. However, their anti-inflammatory properties can be counterproductive. This is because the inflammation can provoke the body to heal, which means that the PRP injections are more likely to be effective within a shorter period.
  • Procedure: The treatment begins by drawing blood from your arm. The PRP in your blood will then be separated and injected back into your body at the site of the injury. Using ultrasound guidance, the PRP will be injected into the proper ligaments, tendons, and joints. The entire procedure shouldn’t take more than 30 minutes.
  • Post-Treatment: You should avoid washing or using lotions on the area where the PRP was injected for at least 48 hours. Additionally, if the PRP treatment was injected into your tendons, you should avoid strenuous exercises or activities for two to three weeks. As for side effects, expect the injection site to feel sore for a few days. You may also experience mild swelling, bruising, and numbness in the area as well. However, those effects should go away within a couple of days.

Gain The Benefits Of High-Dose PRP Injections

At Orthagenex, we provide high-dose PRP injections as an effective and safe treatment option for spondylolisthesis. As an alternative to surgery, our PRP injections provide long-term pain relief while promoting the body’s natural healing process. In addition, they’re minimally invasive and require a much shorter recovery than surgery.

If you’re considering PRP injections for spondylolisthesis, we encourage you to contact us for more information and discuss your treatment options. We look forward to helping you achieve relief from chronic spondylolisthesis pain and help improve your quality of life.

High Dose PRP for Low Back Pain

More often than not, when a patient is suffering from some sort of pain, it can be directly tied to some irritation in the back. Whether the pain is high or low, it is likely that many can claim to have experienced it at one point or another. Low back pain is extremely common and manifests mostly in people who are obese or have suffered injury throughout their lifetime. However, low back pain can be a result of many different conditions besides injury and these conditions can require years of therapy and management. While most pain experienced is mild and manageable, many patients experience pain that is debilitating and precludes them from completing any normal, day-to-day activities. Although there are several different causes for low back pain, patients should understand that the pain is manageable through various treatment options.

When patients know and understand the conditions and causes of their low back pain, they are more likely to find a treatment that works and makes sense to them. While the most common treatment methods are sought out at home, some may consider drastic surgical options. For patients who seek a nonsurgical treatment and a treatment without addictive or risky medications, Orthagenex offers the treatment of high dose platelet rich plasma, High Dose PRP. However, before we cover the ins and outs related to high dose platelet rich plasma, we will review some of the aspects of low back pain so that patients could more easily pinpoint their condition.

When faced with the effects of lower back pain, patients will often resort to massaging the lower back without realizing that their pain is likely the result of nerves firing and not muscles being overworked. People often assume the pain is a result of muscle fatigue because the affected area is often the same area, they would feel pain in after heavy-lifting. While heavy lifting over an extended period of time could result in back pain, the pain is often a symptom of a deeper problem. Without confirmation of a condition, it would come to no surprise that patients experience frustration after massaging the affected area to no relief. The first thing that patients with lower back pain need to understand is that most lower back pain is a result of the nerves in their lower back being agitated. The first step in seeking effective treatment is learning what is wrong with our bodies. Once we know and understand what our bodies are communicating to us, we can assess the situation, seek effective treatment, and overcome our bodies’ obstacles with confidence.

Some of the most common causes for lower back pain might not be readily apparent to patients and may take a proper diagnosis from a medical professional before starting the recommended treatment. As mentioned previously, most people will experience lower back pain in their lives, and it will likely become an issue for which most would seek medical attention. At the same time, some patients who seek medical attention might have experienced an acute injury that spurred them into action. However, the types of patients who seek medical attention for lower back pain will often be divided into subsets before doctors recommend them for a particular treatment. So, like medical professionals, when considering the causes of lower back pain, we must also consider these various subsets of patients who are categorized by the conditions they face that would be considered risk factors.

The first, most prominent qualifier for the cause of lower back pain is age. Lower back pain is most common with patients who are over the age of thirty and the likelihood increases from then on. This is not to say that patients under thirty cannot or will not experience back pain, but it is more likely that a patient who is experiencing back pain will be over the age of thirty. Unfortunately, age is a risk factor for most conditions including lower back pain and this is due to the wearing down of disks that sit along the vertebrae of the human spine. Over time, these soft and flexible disks that can absorb the impact and stretching required from physical activity, become more brittle and unable to support the weight placed upon the vertebrae of the spine. In addition to the wearing down of these discs, it is often the case that low back pain is a result of a herniated disc– a condition wherein the disc ruptures.

The issue of accomplishing physical tasks is further exacerbated by the weight of an individual. The extra and unnecessary weight of an individual will strongly contribute to the pain experienced in the lower back. Because we ask our spine to handle hundreds of tasks which can often be strenuous every day, adding extra weight to the spine would further increase the pain experienced by patients with lower back pain. Dr. Lee and his associates in the International Journal of Environmental Research and Public Health explain that “[f]irst, as weight increases, a load is placed on the joint carrying the weight, and compression of the intervertebral disc may be induced due to axial loading on the lumbar spine, one of the major joints carrying the weight, and this may lead to injury. Second, weight gain can cause spinal malalignment, especially lumbar lordosis, leading to LBP [low back pain]. Third, the increase in adipose tissue as the body weight increases secretes cytokines such as tumor necrosis alpha and interleukin 6, which contribute to the development of pain via the alteration of neurophysiological properties of peripheral nociceptors and central neurons” (2021). With these complications related to weight in mind, patients will likely consider the lifestyle choices they have made and will make to manage their low back pain.

Weight is often a result of an individual’s occupation or lifestyle. Unfortunately, those who live or work in an environment that is more sedentary and requires the patient to sit for several hours at a time have a much higher chance of being overweight and experiencing greater low back pain. Patients who live or work in such environments may be surprised to learn that their environment can cause lower back pain because it is not requiring them to do any strenuous exercise or activities. Contributing factors for low back pain, while surprising, are no less serious and vary from the aforementioned qualifiers to osteoarthritis and even depression or anxiety.

With these conditions and qualifiers in mind as causes for low back pain, we must also consider a condition that is directly tied to the nerves along the lower back; sciatica. Sciatica, being a condition that results from the pinching of the sciatic nerve, may also be directly tied to the disks along the vertebrae that compress the nerve. So, if the nerve is compressed by the disks, the disks along the spine are also wearing out over time, and a patient suffers from any of the former qualifiers, one can begin to understand that low back pain is a condition that is complex and multifaceted. At the outset in search of treatment, patients should understand that their low back pain is likely a result of more than one contributing factor. Because of the enumeration of conditions that contribute to low back pain, patients will often feel discouraged and assume that there is no one-size-fits-all solution to their back pain. While most patients may know of and utilize temporary pain-relievers, all would rather have effective, safe, and lasting treatment without risking surgery.

For a more safe and effective form of low back pain treatment, patients and doctors are more frequently turning to platelet rich plasma (PRP) Dr. Akeda and her associates in the Journal of Pain Research who research the efficacy of PRP for low back pain first explain that, “[p]latelet-rich plasma (PRP) is an autologous blood concentrate that contains a natural concentration of autologous growth factors and cytokines and is currently widely used in the clinical setting for tissue regeneration and repair. PRP has great potential to stimulate cell proliferation and metabolic activity of IVD [in vitro diagnosis] cells in vitro” (2019). The more physicians research and apply PRP for treatment purposes, the more they find promising results.

The study continues to claim that, “[s]everal animal studies have shown that the injection of PRP into degenerated IVDs is effective in restoring structural changes (IVD height) and improving the matrix integrity of degenerated IVDs as evaluated by magnetic resonance imaging (MRI) and histology. The results of this basic research have shown the great possibility that PRP has significant biological effects for tissue repair to counteract IVD degeneration”. These several studies, while showing promising results in animals can also be applied to use in human research when it comes to low back pain treatment.

The research article concludes that, “[c]linical studies for evaluating the effects of the injection of PRP into degenerated IVDs for patients with discogenic LBP have been reviewed. Although there was only one double-blind randomized controlled trial, all the studies reported that PRP was safe and effective in reducing back pain. While the clinical evidence of tissue repair of IVDs by PRP treatment is currently lacking, there is a great possibility that the application of PRP has the potential to lead to a feasible intradiscal therapy for the treatment of degenerative disc diseases. Further large-scale studies may be required to confirm the clinical evidence of PRP for the treatment of discogenic LBP” While these results are certainly promising, patients might wonder if PRP is the best treatment when compared to other similar types of treatment.

Dr. Xuan and his associates in the Journal of Neurological Surgery, first explain that, “PRP is an autologous blood derivative containing high concentrations of activated growth factors and cytokines (e.g., platelet-derived growth factor, transforming growth factor, fibroblast growth factor, insulinlike growth factor 1, and epidermal growth factor). These elements serve as important humoral mediators to induce an anti-inflammatory effect and natural healing cascade by promoting cell proliferation, migration and differentiation, protein transcription, extracellular matrix regeneration, angiogenesis, and collagen synthesis” (2020). All of these elements mentioned by Dr. Xuan and his associates not only prove to make PRP an effective treatment, but a safe treatment when compared to its competitors.

The doctors continued their study and found that, “Our meta-analysis concluded that PRP injection resulted in significantly improved pain relief (as evidenced by the meta-analysis of pain scores within 8 weeks and > 50% pain relief at 3 months) and patient satisfaction for patients with low back pain. In addition, one included RCT revealed that PRP injection was able to result in sustained and more reduction in pain visual analog scores and lumbar functional improvements at the end of 6 months than local anesthetic using a corticosteroid. These results indicated autologous PRP served as the superior treatment option for longer duration efficacy for low back pain compared with corticosteroids”. Not only do patients have the added benefit of longer duration away from pain, but they will also avoided unwanted complications from corticosteroid injections. In conclusion, Dr. Xuan found that, “PRP injection showed an important ability to provide pain relief and patient satisfaction for those with low back pain”.

Regardless of a patient’s history with low back pain, whether it is a result of an acute injury, or whether they have tried every treatment in the book, Orthagenex High Dose PRP, platelet rich plasma, proves to be the standard for treatment. When patients are treated with high dose PRP, they will experience a higher quantity and quality of these growth factors that promote cellular regeneration and tissue regrowth. When high dose PRP is administered to patients, there is a high likelihood that they will see results immediately because Orthagenex High Dose PRP facilitates the body’s ability to treat itself in a concentrated form. With this treatment, patients don’t need to worry about where the relief will be or whether they will return to a higher quality of life and activity. The treatment is here with Orthagenex High Dose PRP, the most advanced platelet rich plasma treatment available today.

High Dose PRP for Herniated Disc

When it comes to back pain, the fact is that there are many conditions that could contribute. Most patients with back pain will be able to point to a specific incident of acute injury or be able to accurately explain the chronic condition contributing to the pain, but for many patients back pain can be elusive and difficult to understand. One such condition that many do not understand is what’s known as a herniated, slipped, bulged, or ruptured disc. All of these terms refer to the same or similar condition and instance that brought the condition about but for the purposes of this article, we will be referring to the condition as a herniated disc. Understanding the occurrence and pathogenesis of a herniated disc is a patient’s first step in seeking proper diagnosis and treatment for the pain.

For patients with a herniated disc, the pain can seem insurmountable and preclude any necessary physical activities. It has often been reported that the symptoms include general back pain and weakness but what some patients may not know is that a herniated disc can also affect arms and legs in the same way. One may wonder how a herniated disc in the spine could affect these other areas, however it is essential that they do. If patients are unable or unwilling to understand how a herniated disc can contribute to arm/leg weakness and pain, they may attribute these symptoms to other conditions that can lead to misdiagnosis and potentially improper treatment.

The first thing to understand about any level of pain is that it is all directly tied to our central nervous system that runs along the spine. Pain nerves (or fibers) that run along the central nervous system also extend to the lengths of our legs and arms, what is also known as our peripheral nervous system. It is for this reason that many patients who suffer from diabetes also experience peripheral neuropathy– a condition that contributes to lasting hand and feet numbness and pain. It is common for one injury to spur other issues and pain conditions across the body. A similar condition that originates in the spine and extends to other areas of the body is sciatica. Patients with sciatica will typically feel pain along their hip or leg not knowing that the pain is a result of a pinched nerve in their spine. Because of improper understanding of the condition, a herniated disc sits alongside these conditions as one that is typically misdiagnosed and inadequately treated. So, what exactly is a herniated disc and why does it affect these outlying areas.

Dr. Wai Weng Yoon of the Spinal Surgery Unit in Leicester, UK, surmises the condition of a herniated disc as, “a localized displacement of disc material beyond the normal margins of the intervertebral disc space” (2021). Simply put, a herniated disc occurs when the cushion of disc that sits between the vertebrae to provide flexibility and protection ruptures. This rupture pushes part of the disc outside of its typical circumference.

Dr. Yoon continues to explain that “[t]he pain pathway originates in impingement [pinching] of the nerve root by the herniated disc, which may in turn lead to nerve damage both by mechanical and chemical pathways. Mechanically, compression of the nerve likely leads to localized ischemia [blood flow blockage] and nerve damage”. If there is one condition to which patients could look for similar understanding, it is the previously mentioned condition of sciatica. When a patient understands the central nervous system and how conditions along the spine contribute to other areas of pain in the body, they will more frequently and accurately diagnose these conditions and seek proper treatment.

One of the most promising treatments for pain, including pain from a herniated disc, is the treatment of platelet rich plasma. Many patients have not heard of platelet rich plasma and are understandably wary of any treatment that might be novel, perhaps fearing that it is not tried and true. But for platelet rich plasma, the evidence for its treatment capability is clear. In a study examining the effects of platelet rich plasma as an intradiscal (spinal disc) treatment, Dr. Tuakli-Wosorno and his associates concluded that, “[p]articipants who received intradiscal PRP showed significant improvements in FRI [Functional Rating Index], NRS [Numeric Rating Scale] Best Pain, and NASS [North American Spine Society] patient satisfaction scores over 8 weeks compared with controls. Those who received PRP maintained significant improvements in FRI scores through at least 1 year of follow-up” (2016). Even with these results, patients might maintain a healthy skepticism surrounding platelet rich plasma as a treatment for herniated discs. In this case it may be necessary for patients to examine which treatment options are available and how they compare with platelet rich plasma.

In a more recent study examining the efficacy of platelet rich plasma against steroid injections, doctors Zhen Xu and her associates determined that their intentions were, “ . . . aimed at comparing the efficacy and safety aspects between ultrasound-guided transforaminal injections of PRP and steroid in patients who suffer from radicular pain due to lumbar disc herniation” (2021). The study included, “a total of 124 patients who suffer from radicular pain due to lumbar disc herniation. Patients were assessed by the visual analogue scale (VAS), pressure pain thresholds (PPTs), Oswestry disability index (ODI), and the physical function (PF) and bodily pain (BP) domains of the 36-item short form health survey (SF-36) before operation and 1 week, 1 month, 3 months, 6 months, and 12 months after operation”. While it was eventually concluded that PRP has a similar level of efficacy when compared to steroid injections, the physicians ultimately determined that, “. . . ultrasound-guided transforaminal PRP injections yield similar effect as transforaminal steroid injections in treating lumbar disc herniation with radicular pain and that it may be a safer alternative in comparison”. With all this in mind, patients may still be apprehensive to seek platelet rich plasma as a treatment for their herniated disc. Understanding how platelet rich plasma treats this condition may help assuage some of this hesitation.

Before concluding that PRP is comparable to steroid injections and likely safer, doctors Zhen Xu and her associates explained the development and efficacy of platelet rich plasma: “In recent years, PRP has been widely used in treating musculoskeletal diseases due to its anti-inflammatory properties and ability in promoting the processes of endogenous healing by delivering a high concentration of growth factors and cytokines. These growth factors, such as vascular endothelial growth factor (VEGF), transforming growth factor β-1 (TGFβ-1), platelet-derived growth factor (PDGF), and insulin-like growth factor-1 (IGF-1), are contained within the α-granules of platelets. Within 10 minutes after PRP injection, the platelets aggregate and clot at the targeted site with almost 95% of the α-granules load being secreted within 1 hour. Studies have shown that these growth factors are effective in promoting proliferation, angiogenesis, and synthesis of extracellular matrix proteins. Therefore, the key rationale behind the application of PRP is to increase the concentration of platelets at the targeted sites so that cytokines and GFs may be released. This will consequently allow the regulation of inflammation and immunological responses of tissue healing”. Because platelet rich plasma facilitates and aggregates these growth factors along a herniated disc, it is one of the most requested forms of treatment available today. It is also popular because it is a solution provided by the patient’s own blood.

In an evaluation of PRP conducted by the China-Japan Union Hospital of Jilin University, researchers explain that “[p]latelet-rich plasma (PRP) is a platelet concentrate extracted from autologous blood by centrifugation, which is a kind of bioactive substance” (2022). Patients might wonder how this works and whether it is safe– especially when hearing Dr. Wang refer to it as a “bioactive substance”. It is likely that many would be unwilling to apply a “bioactive substance” to treat a herniated disc. However, as is always the case, further evaluation and a deeper understanding of platelet rich plasma will help patients understand its legitimacy as a treatment for a herniated disc. With the advancement of medical technology, Orthagenex is now able to assist the body in treating herniated disc pain through high dose platelet rich plasma.

From autologous blood (a patient’s own blood), Orthagenex is able to take platelets in a concentrated form. When blood is taken from us and put in a centrifuge, it is spun around quickly to separate red blood cells from white blood cells as well as concentrate the number of platelets together. These concentrated platelets, once extracted and applied to a herniated disc, act as a supplemental regrowth. With Orthagenex High Dose PRP, patients with herniated discs will have options and hope through high dose platelet rich plasma. Orthagenex offers the treatment, education, and follow-up that patients need to return to and maintain a renewed level of confidence and understanding in their condition. Without the worry of invasive procedures or unpredictable medications, patients can have hope and confidence in their ability to find how treatments like High Dose PRP, platelet rich plasma, work for them.

High Dose PRP, Platelet Rich Plasma, as a Treatment for Epicondylitis

Differing locations and levels of pain throughout the body can be perplexing to the average person who is experiencing or learning about their pain. One minute, a patient might be experiencing pain in one location of their body and the next their pain has vanished or relocated. Typically, Orthagenex works to help patients treat chronic conditions by non-invasive means. However, there are some conditions that can be both chronic long-term issues that present routinely as short-term repeat episodes of inflammation and pain. Epicondylitis, both lateral and medial, is one such condition that perplexes patients who suffer from it. However, regardless of a patient’s history or constancy with the condition, Orthagenex understands that effective pain relief can be difficult to find– especially when the condition needing treatment is not easily understood. So, what is lateral/medial epicondylitis and how can Orthagenex help?

In 2013, Dr. Ahmad and his associates in The Bone & Joint Journal conducted an extensive study on the nature of epicondylitis and first determined that, “[l]ateral epicondylitis, or ’tennis elbow’, is a common condition that usually affects patients between 35 and 55 years of age. It is generally self-limiting, but in some patients, it may continue to cause persistent symptoms, which can be refractory [stubborn] to treatment” (Ahmad, 2013). Because of the condition’s sporadic influence on a patient and symptoms that prevent regular treatment, patients are often left frustrated and confused. However, learning more about the condition and its vagaries can help.

Dr Ahmad continued to pursue the elusive condition and its effects on patients and determined that epicondylitis, “ . . . affects between 1% and 3% of the population, mainly those aged from 35 to 55 years, with an equal gender distribution. It is generally self-limiting, and most cases require no more than treatment with simple analgesia . . . Although popularly associated with tennis, lateral epicondylitis may develop from a variety of activities that involve excessive and repetitive use of the forearm extensors,18 such as typing, playing the piano and various types of manual work. When affected, any movement that puts force on the extended wrist may be painful, as it increases the load on the diseased common extensor tendon”. When understanding that epicondylitis can result from activities as innocuous as playing the piano, patients can begin to understand why the condition is so sporadic in nature; they may not realize the various activities they perform every day could trigger and inflame the condition.

However, as Ahmad previously mentioned, epicondylitis is commonly referred to as “tennis elbow” and this is for a very good reason. Dr. Ahmad, in a summary of the relation between tennis and epicondylitis concluded that, “racquet sports may cause the condition due to a combination of factors: 1) incorrect technique (snapping the wrist in a backhand play, incorrect positioning of the feet, and hitting the ball late or with a bent elbow all result in power generation from the forearm extensors rather than core muscles or the rotator cuff); 2) extended duration of play; 3) frequency of play; 4) size of the racquet handle (affecting the lever arm of the force applied through the forearm); and 5) racquet weight”. While it is likely and obvious that many patients who suffer from “tennis elbow” are involved in some form of racquet sport, there are of course other contributing factors.

Dr. Ahmad in studying the origin of epicondylitis also concludes that, “[w]ork-related lateral epicondylitis may be linked to handling tools heavier than 1 kg, loads heavier than 20 kg more than ten times per day, and repetitive movements for more than two hours”. In general, it may be assumed that anyone who does repetitive motion with their arms and/or lifts heavy loads regularly may experience some level of pain from epicondylitis. With this being the case, it is no surprise that many who suffer from the condition will ask what they can to decrease the pain and increase mobility in their arms.

While many seek treatment for epicondylitis, others maintain that the condition– in its ephemeral nature– will eventually dissipate. In 2019, Dr. Lenoir and his associates in the journal of Orthopaedics & Traumatology: Surgery & Research determined that, “LE usually resolves spontaneously without treatment within 1–2 years. Very few studies have compared outcomes with and without treatment. As a result, whether a favourable outcome should be ascribed to the treatments used or to the natural history of the disorder is unclear . . . Overall, the available data suggest that LE often resolves spontaneously. Therefore, considerable circumspection is in order before embarking on a course of treatment, regardless of the modality chosen. Studies comparing specific types of treatment versus placebo are needed”. However, while patients often experience the pain of epicondylitis spontaneously resolve without treatment, many will experience the pain for extended periods of time and won’t necessarily appreciate being told to wait until the pain subsides. For patients who want to be proactive in treating their epicondylitis, there is a recommended treatment offered by Orthagenex.

In Dr. Ahmad’s same study mentioned previously in The Bone & Joint Journal, he and his associates found that, “[p]latelet-rich plasma (PRP) is a concentrate of platelets derived from the patient’s own blood and is known to contain a high content of growth factors that have the potential to enhance the healing process of the tendon [related to epicondylitis]. A blood sample is taken and centrifuged to extract the plasma content, and the blood is then re-injected around the lateral epicondyle. A number of RCTs have shown that PRP is superior to autologous blood and bupivacaine injections” (2013). With an understanding of the procedure and hope that it could be an effective treatment for epicondylitis, patients may wonder how Orthagenex uses high dose PRP treatments and what studies prove that it is an effective treatment.

In separate trials focusing on the efficacy of platelet rich plasma versus other methods in treating epicondylitis, Dr. Ahmad explains that, “[t]wo cohort studies showed that PRP improved clinical satisfaction scores. One case-control study showed that PRP yielded a significantly greater improvement in symptoms compared with bupivacaine [a local anesthetic]. Two randomized controlled trials compared the effect of injections of PRP and blood. Only 1 of the studies noted a significant difference at the 6-week time point. Three randomized controlled trials compared corticosteroids with PRP. Two of the smaller trials, which had follow-up periods of 6 weeks and 3 months, showed no significant difference between treatment groups. The largest randomized controlled trial found that PRP had significant benefit compared with corticosteroids with regard to pain and Disabilities of the Arm, Shoulder and Hand scores at 1- and 2-year time points” (2013). As we can clearly see, patients undergoing high dose PRP treatments with Orthagenex have a high likelihood of treating the pain symptoms of epicondylitis. Dr. Ahmad concludes that these clinical trials are “. . . limited but evolving evidence for the use of PRP in lateral epicondylitis”.

As the use of High Dose PRP treatment has increased, the trials and understanding of the treatment has only provided further advocacy for its recommendation in treating epicondylitis. In a more recent 2019 study, Dr. Boden determined that, “ME and LE [Medial and Lateral Epicondylitis] are common conditions that affect between 1% and 3% of the population, mainly in persons aged 35 to 55 years . . . Although a multitude of treatment options are available, there is currently no clear gold-standard treatment for patients with chronic pain. With the aging population, successful, less invasive treatment modalities are essential” With the necessity for less invasive treatment options, Dr. Boden determined that, “PRP . . . procedures are effective, minimally invasive, nonsurgical options for treating recalcitrant [again, stubborn] ME or LE. “. . . showed a clinically and statistically significant improvement in pain and function”. As our understanding of this condition continues to evolve, Orthagenex offers the premier solution for patients with epicondylitis through high dose PRP treatment.

Patients who undergo these high dose PRP treatments for their epicondylitis pain will not only experience a safe and effective way to mitigate the pain but become further educated in the nature of their condition. The more a patient understands the nature of their pain condition, even a condition as unpredictable as epicondylitis, the more they will come to understand how Orthagenex High Dose PRP treatments may work for them. Improving one’s understanding of painful conditions not only educates patients to help them seek effective treatments like high dose PRP but gives them the confidence they need to make informed and productive decisions. Throughout this process, Orthagenex is here to help– all with the aim of improving a patient’s quality of life and reducing irritating pain.

High Dose PRP for Knee Pain

At times, when patients with knee pain are at their most vulnerable, it can seem next-to-impossible to believe in a treatment that can help. What’s worse, when patients experience knee pain on a daily basis, hope in alleviating the pain seems to disappear rapidly. As patients live with the effect of knee pain, accomplishing most physical tasks might seem insurmountable. However, knee pain is treatable and depending on the patient’s level of comfort with the treatment options, the treatment can be effective. Patients who do not wish to undergo invasive surgeries or potentially harmful side-effects from various prescriptions might become apprehensive when learning that most treatments for knee pain are not without side-effects. However, there is at least one treatment that is both effective and safe– platelet rich plasma (PRP).

Along with concerns over the side-effects and efficacy of treatments, when patients are exploring these treatment options with their doctors, they should also recognize the level of pain is likely based on their history of knee pain– or pathogenesis. While maintaining the objective of seeking effective treatment, it is likely that many will not consider the development of their knee pain, contributing risk factors, or what they can do on their own to treat the pain. When a patient does not do the research into their knee pain or understand the conditions that caused their pain, they are less likely to give their doctors a clear picture of their day-to-day conditions. The more accurate a patient understands and can describe their condition, the more likely they are to be given proper treatment.

While patients and their doctors determine the most suitable treatment for their condition, there are many factors that patients should consider– considerations we wish to engender into the minds of patients so that they can choose a treatment and an associated plan that is best for them. With an aim to educate and inform the increasing populace who suffers from chronic knee pain, it is only appropriate that patients be informed on the developments, successes, and failures associated with chronic knee pain treatment. In the end, while it is likely patients will experience frustration in their quest for treatment, treatment for knee pain does exist and it exists with Orthagenex High Dose PRP treatment.

To begin, let us differentiate and categorize the two most common types of knee pain. When it comes to knee pain, there must be a clear distinction of which patients are made aware. When a patient knows the origin and conditions associated with their knee pain, they will be more able to effectively find a treatment for themselves. Knee pain can either derive from chronic or acute conditions. Acute knee pain heals relatively quickly and refers specifically to pain that has lasted less than six months and is usually the result of an injury. The most common cause of chronic knee pain is osteoarthritis. Once patients understand osteoarthritis as a contributing factor to knee pain, they can begin to understand how other risk factors can contribute and combine to aggravate knee pain. But first, what is osteoarthritis?

Dr. Dragan Primorac highlights the importance of paying attention to osteoarthritis (OA) by stating that, “[i]t is estimated that the prevalence of knee osteoarthritis (OA) among adults 60 years of age or older is approximately 10% in men and 13% in women, making knee OA one of the leading causes of disability in elderly population. Today, we know that osteoarthritis is not a disease characterized by loss of cartilage due to mechanical loading only, but a condition that affects all of the tissues in the joint, causing detectable changes in tissue architecture, its metabolism and function” (2020). With such a high populace suffering from knee osteoarthritis, its related pain, and deformations, physicians like Dr. Primorac are scrambling daily for a solution and effective treatment upon which their patients can rely.

Osteoarthritis, a condition that affects nearly 40 million in the United States, is a condition that often manifests in the fingers and toes of patients who have been diagnosed with it, but patients who suffer from OA can expect to experience its symptoms in most joints throughout the body and this is especially true for the joints in the knee. OA manifests itself with symptoms of bone spurs, stiffness, and pain specifically targeting the joints. OA, is the most common form of arthritis because it affects most people.

One may question how that is possible and how so many people can experience arthritis, the answer is simple; everyone ages. Over time the internal and external anatomical structure of our body’s breakdown and the risk for osteoarthritis increases as the body ages. Osteoarthritis occurs when the protective pads of cartilage are worn down and the bones grind against each other and cause this pain. Unfortunately, everyone is at risk for osteoarthritis. However, patients who have experienced injuries to their knees or other joints are more likely to experience arthritis at an older age and OA is further exacerbated by other risk factors– such as obesity.

Dr. Lianzhi Chen and her associates summarize the experience of patients and their pathogenesis of knee pain by claiming that, “[o]besity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause significant impact on patients’ quality of life” (2020). Dr. Chen recognizes, along with most physicians working to mitigate knee pain with their patients, that obesity is an intrinsic contribution to osteoarthritic knee pain.

In a further summary on the impact of a heavy load and OA on knee pain, Dr. Chen states that, “[m]oderate dynamic mechanical loading is one of the most important mechanical factors for maintaining joint homeostasis. The integrity of articular cartilage is maintained under moderate loading conditions during routine daily activities. However, when receiving abnormal excessive mechanical loading, disruption of cartilage homeostasis and deformation of normal joint morphology occurs, further inducing and accelerating the progression of OA”. While it may seem to be common sense to many that knee pain would increase with the increase of a patient’s weight, many do not consider– as Dr. Chen states– that obesity can accelerate the pathogenesis of osteoarthritis.

Not only does excess weight increase knee pain but it can literally deform the knee joint itself, further complicating the pain and necessitating more drastic treatment intervention. When patients are seeking treatment that is both effective and lasting, they are often met with disappointment and frustration. For doctors presented with these emotions from their patients, the former is frustrating and the latter is understandable. For too long, patients and doctors have looked for a treatment that assuages the pain while being safe and without side-effects. For many, a treatment of this nature might seem impossible or at least out of reach. With Orthagenex, treatment exists for knee pain– a treatment that promises efficacy, safety, and results.

In a study evaluating the efficacy of platelet rich plasma asa treatment for knee pain, Dr. Araya and her associates found that, “[i]n all groups, PRP increased the load-sharing ratio on PRP-injected knees, with pure PRP eliciting the largest effect among the 3 kinds of PRP (P < .05). Structural changes in the synovial tissue were significantly inhibited in the pure-PRP group compared with the control group after both 5 and 14 days (P < .001 and P = .025, respectively), whereas no significant difference was found between the control, LP-PRP, and LR-PRP groups. An inhibitory effect on cartilage degeneration was observed only in the pure-PRP group on day 14. Pure PRP also significantly inhibited expression of CGRP-positive nerve fibers in the infrapatellar fat pad compared with the other groups (P < .05)” (2020). In short, the research suggests that, “[i]n an MIA-induced arthritis model, pure PRP injection was the most effective treatment for reduction of pain-related behavior and inhibition of synovial inflammation and pain sensitization . . . PRP formulations should be optimized for each specific disease. This study shows the superiority of pure PRP for treatment of arthritis and joint pain”. In light of this positive news, patients might still be skeptical and wonder how this form of treatment stacks up against other non-invasive forms of treatment for knee pain.

In a more specific study analyzing the difference between PRP and hyaluronic acid injections to treat knee pain, Dr. Chen and his associates explain that, “a common conservative treatment, intra-articular injection of hyaluronic acid (HA) can regulate vascular permeability, lubricate the joints, reduce joint loading, and promote wound healing” (2020). In contrast, these medical professionals also found that, “[i]n recent years, there has been increasing attention focused on the intra-articular injection of platelet-rich plasma (PRP). PRP is a concentrate of platelets derived from whole blood by centrifugation that contains a large quantity of proteins and growth factors, including platelet-derived factors and transforming growth factor β. It is believed to support various important physiological functions such as anti-inflammation, analgesia, pro-proliferation of chondrocytes, and cartilage repair”. With this description in mind, patients can begin to see why and how PRP injections could very easily facilitate the regrowth and repair of cartilage damaged through years of osteoarthritis and/or acute injury.

In the end, Dr. Chaen and his associates concluded that, “[c]ompared with HA, PRP offers more advantages in the conservative treatment of knee osteoarthritis, including reduced long-term pain and improved knee joint function. PRP has no evident additional risk and can be widely used as a conservative treatment for knee osteoarthritis”. Orthagenex High Dose PRP treatment guarantees that patients are not forever locked to knee pain, even if that knee pain has been exacerbated with osteoarthritis or obesity. When patients experience high dose PRP injections, they will also be given a full nutrient deficiency rejuvenation to guarantee that a patient’s immune system is working for them to treat the chronic knee pain.

With Orthagenex, patients can be sure that they will have an experience that relieves pain, restores health, and magnifies quality of life without medications, surgeries, or invasive procedures. Orthagenex High Dose PRP, platelet rich plasma, facilitates the body’s natural ability to heal itself and repair damaged joints in the knee. For platelet rich plasma, the research is clear, and patients no longer need to worry about whether or not they need to go another day experiencing knee pain.