High Dose PRP for Knee Pain

by Katy

At times, when patients with knee pain are at their most vulnerable, it can seem next-to-impossible to believe in a treatment that can help. What’s worse, when patients experience knee pain on a daily basis, hope in alleviating the pain seems to disappear rapidly. As patients live with the effect of knee pain, accomplishing most physical tasks might seem insurmountable. However, knee pain is treatable and depending on the patient’s level of comfort with the treatment options, the treatment can be effective. Patients who do not wish to undergo invasive surgeries or potentially harmful side-effects from various prescriptions might become apprehensive when learning that most treatments for knee pain are not without side-effects. However, there is at least one treatment that is both effective and safe– platelet rich plasma (PRP).

Along with concerns over the side-effects and efficacy of treatments, when patients are exploring these treatment options with their doctors, they should also recognize the level of pain is likely based on their history of knee pain– or pathogenesis. While maintaining the objective of seeking effective treatment, it is likely that many will not consider the development of their knee pain, contributing risk factors, or what they can do on their own to treat the pain. When a patient does not do the research into their knee pain or understand the conditions that caused their pain, they are less likely to give their doctors a clear picture of their day-to-day conditions. The more accurate a patient understands and can describe their condition, the more likely they are to be given proper treatment.

While patients and their doctors determine the most suitable treatment for their condition, there are many factors that patients should consider– considerations we wish to engender into the minds of patients so that they can choose a treatment and an associated plan that is best for them. With an aim to educate and inform the increasing populace who suffers from chronic knee pain, it is only appropriate that patients be informed on the developments, successes, and failures associated with chronic knee pain treatment. In the end, while it is likely patients will experience frustration in their quest for treatment, treatment for knee pain does exist and it exists with Orthagenex High Dose PRP treatment.

To begin, let us differentiate and categorize the two most common types of knee pain. When it comes to knee pain, there must be a clear distinction of which patients are made aware. When a patient knows the origin and conditions associated with their knee pain, they will be more able to effectively find a treatment for themselves. Knee pain can either derive from chronic or acute conditions. Acute knee pain heals relatively quickly and refers specifically to pain that has lasted less than six months and is usually the result of an injury. The most common cause of chronic knee pain is osteoarthritis. Once patients understand osteoarthritis as a contributing factor to knee pain, they can begin to understand how other risk factors can contribute and combine to aggravate knee pain. But first, what is osteoarthritis?

Dr. Dragan Primorac highlights the importance of paying attention to osteoarthritis (OA) by stating that, “[i]t is estimated that the prevalence of knee osteoarthritis (OA) among adults 60 years of age or older is approximately 10% in men and 13% in women, making knee OA one of the leading causes of disability in elderly population. Today, we know that osteoarthritis is not a disease characterized by loss of cartilage due to mechanical loading only, but a condition that affects all of the tissues in the joint, causing detectable changes in tissue architecture, its metabolism and function” (2020). With such a high populace suffering from knee osteoarthritis, its related pain, and deformations, physicians like Dr. Primorac are scrambling daily for a solution and effective treatment upon which their patients can rely.

Osteoarthritis, a condition that affects nearly 40 million in the United States, is a condition that often manifests in the fingers and toes of patients who have been diagnosed with it, but patients who suffer from OA can expect to experience its symptoms in most joints throughout the body and this is especially true for the joints in the knee. OA manifests itself with symptoms of bone spurs, stiffness, and pain specifically targeting the joints. OA, is the most common form of arthritis because it affects most people.

One may question how that is possible and how so many people can experience arthritis, the answer is simple; everyone ages. Over time the internal and external anatomical structure of our body’s breakdown and the risk for osteoarthritis increases as the body ages. Osteoarthritis occurs when the protective pads of cartilage are worn down and the bones grind against each other and cause this pain. Unfortunately, everyone is at risk for osteoarthritis. However, patients who have experienced injuries to their knees or other joints are more likely to experience arthritis at an older age and OA is further exacerbated by other risk factors– such as obesity.

Dr. Lianzhi Chen and her associates summarize the experience of patients and their pathogenesis of knee pain by claiming that, “[o]besity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause significant impact on patients’ quality of life” (2020). Dr. Chen recognizes, along with most physicians working to mitigate knee pain with their patients, that obesity is an intrinsic contribution to osteoarthritic knee pain.

In a further summary on the impact of a heavy load and OA on knee pain, Dr. Chen states that, “[m]oderate dynamic mechanical loading is one of the most important mechanical factors for maintaining joint homeostasis. The integrity of articular cartilage is maintained under moderate loading conditions during routine daily activities. However, when receiving abnormal excessive mechanical loading, disruption of cartilage homeostasis and deformation of normal joint morphology occurs, further inducing and accelerating the progression of OA”. While it may seem to be common sense to many that knee pain would increase with the increase of a patient’s weight, many do not consider– as Dr. Chen states– that obesity can accelerate the pathogenesis of osteoarthritis.

Not only does excess weight increase knee pain but it can literally deform the knee joint itself, further complicating the pain and necessitating more drastic treatment intervention. When patients are seeking treatment that is both effective and lasting, they are often met with disappointment and frustration. For doctors presented with these emotions from their patients, the former is frustrating and the latter is understandable. For too long, patients and doctors have looked for a treatment that assuages the pain while being safe and without side-effects. For many, a treatment of this nature might seem impossible or at least out of reach. With Orthagenex, treatment exists for knee pain– a treatment that promises efficacy, safety, and results.

In a study evaluating the efficacy of platelet rich plasma asa treatment for knee pain, Dr. Araya and her associates found that, “[i]n all groups, PRP increased the load-sharing ratio on PRP-injected knees, with pure PRP eliciting the largest effect among the 3 kinds of PRP (P < .05). Structural changes in the synovial tissue were significantly inhibited in the pure-PRP group compared with the control group after both 5 and 14 days (P < .001 and P = .025, respectively), whereas no significant difference was found between the control, LP-PRP, and LR-PRP groups. An inhibitory effect on cartilage degeneration was observed only in the pure-PRP group on day 14. Pure PRP also significantly inhibited expression of CGRP-positive nerve fibers in the infrapatellar fat pad compared with the other groups (P < .05)” (2020). In short, the research suggests that, “[i]n an MIA-induced arthritis model, pure PRP injection was the most effective treatment for reduction of pain-related behavior and inhibition of synovial inflammation and pain sensitization . . . PRP formulations should be optimized for each specific disease. This study shows the superiority of pure PRP for treatment of arthritis and joint pain”. In light of this positive news, patients might still be skeptical and wonder how this form of treatment stacks up against other non-invasive forms of treatment for knee pain.

In a more specific study analyzing the difference between PRP and hyaluronic acid injections to treat knee pain, Dr. Chen and his associates explain that, “a common conservative treatment, intra-articular injection of hyaluronic acid (HA) can regulate vascular permeability, lubricate the joints, reduce joint loading, and promote wound healing” (2020). In contrast, these medical professionals also found that, “[i]n recent years, there has been increasing attention focused on the intra-articular injection of platelet-rich plasma (PRP). PRP is a concentrate of platelets derived from whole blood by centrifugation that contains a large quantity of proteins and growth factors, including platelet-derived factors and transforming growth factor β. It is believed to support various important physiological functions such as anti-inflammation, analgesia, pro-proliferation of chondrocytes, and cartilage repair”. With this description in mind, patients can begin to see why and how PRP injections could very easily facilitate the regrowth and repair of cartilage damaged through years of osteoarthritis and/or acute injury.

In the end, Dr. Chaen and his associates concluded that, “[c]ompared with HA, PRP offers more advantages in the conservative treatment of knee osteoarthritis, including reduced long-term pain and improved knee joint function. PRP has no evident additional risk and can be widely used as a conservative treatment for knee osteoarthritis”. Orthagenex High Dose PRP treatment guarantees that patients are not forever locked to knee pain, even if that knee pain has been exacerbated with osteoarthritis or obesity. When patients experience high dose PRP injections, they will also be given a full nutrient deficiency rejuvenation to guarantee that a patient’s immune system is working for them to treat the chronic knee pain.

With Orthagenex, patients can be sure that they will have an experience that relieves pain, restores health, and magnifies quality of life without medications, surgeries, or invasive procedures. Orthagenex High Dose PRP, platelet rich plasma, facilitates the body’s natural ability to heal itself and repair damaged joints in the knee. For platelet rich plasma, the research is clear, and patients no longer need to worry about whether or not they need to go another day experiencing knee pain.

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