Understanding What Causes Endometriosis

by Will Bozeman

Endometriosis is an increasingly prevalent condition that affects approximately one in ten women of reproductive age. This painful condition can become debilitating and goes beyond just the physical discomfort; it can also have profound emotional and psychological effects. If you or someone you care for suffers from this complex condition, you probably have questions about what it is and how it develops. 

In this comprehensive article, we share valuable insights into the complex and multifaceted nature of endometriosis. We’ll explain what endometriosis is, shed light on what it can feel like, and explore the various factors that play a role in its development. 

By gaining a deeper understanding of its intricate workings, you can learn more about your individual experiences with endometriosis. This knowledge will guide you toward an accurate diagnosis and a personalized management plan tailored to your needs.

Additionally, we will explore how Neurofunctional Pain Management is revolutionizing how we address endometriosis-related pain, offering hope for those seeking practical, long-lasting relief. 

Firstly, let’s discuss the definition of endometriosis and some of the painful symptoms that impact the lives of the women it affects.

What Is Endometriosis?

Endometriosis is a complex and painful condition that occurs when the lining of the uterus (endometrial tissue) begins to grow outside the uterus. This tissue can infiltrate the structures and organs of the pelvic cavity, causing pain and inflammation, as well as potentially affecting fertility. Endometriosis causes highly individual experiences because it has many types and stages.

What Does Endometriosis Pain Feel Like?

Endometriosis is a unique condition that affects women in many ways; for example, some women may experience no symptoms, whereas the journey is marked by persistent challenges for others.

Symptoms of endometriosis include chronic pain, excruciating periods, heavy bleeding, discomfort during intercourse, altered bowel movements, digestive troubles, and fertility issues. The pain is often described as a sharp abdominal sensation, typically amplified with enduring period cramps. These feelings may ebb and flow in intensity, fluctuating with the hormonal cycle. 

Additionally, the associated symptoms of fatigue, depression, and anxiety can be commonly overlooked or considered a separate problem. However, these symptoms are highly prevalent in people living with endometriosis and are thought to be due to the inflammatory nature of this condition. 

Now that we understand the nature of endometriosis, let’s focus on exploring some of the common causes and influencing factors that lead to its development.

Eight Common Causes Of Endometriosis

Due to its complexity, the exact cause of endometriosis is still unknown. However, researchers have identified several potential contributing factors linked to its development. In the following sections, we will explore these causes and their implications for those affected by this distressing condition.

1. Genetic Predisposition

Genetics is seen to play a crucial role in the development of endometriosis, although it is still not yet completely understood. Here are the three critical genetic factors currently being explored by experts. 

Familial Links And Hereditary Factors

It is well-established knowledge that familial links and hereditary factors significantly influence the risk of developing endometriosis. This means if you have a first-degree relative who has faced this condition, such as your mother, aunt, or sister, your risk of developing it is notably elevated. This also extends to instances of difficulties in fertility within the family, which again suggest a shared genetic vulnerability. However, it is important to note while hereditary factors are underscored as a significant influence, it doesn’t guarantee that you will develop endometriosis. 

Genetic Studies And Identified Susceptibility Genes

There has been an ongoing exploration into the identified genes that increase endometriosis susceptibility. Although there is no specifically identified “endometriosis gene”, there have been certain genes pinpointed that appear to contribute to an increased risk of developing this condition. 


It has been identified that any gene variation that influences the body’s response to hormonal changes, particularly estrogen, has been linked to individuals with endometriosis. This knowledge provides insights into potentially identifiable genetic markers predisposing certain women to develop the condition. However, much like hereditary genes, there are many other factors to consider, and having a gene variation alone does not guarantee the onset of endometriosis.

Epigenetics’ Role In Endometriosis Development

Epigenetics is the study of how genes work or “express” in our bodies. Many factors, such as environmental factors, lifestyle choices, and hormonal influences, can change how a certain gene expresses and functions. These changes can affect how the body reacts to things like hormonal shifts, inflammation, and tissue growth, which are important in endometriosis pathophysiology. 

While epigenetic research is still in its early stages, it is promising to see a deeper understanding of how our genes and the world around us play a part in causing conditions like endometriosis.

2. Hormonal Influences 

The two sex hormones, estrogen and progesterone, play an intricate role in a woman’s reproductive health. The normal hormonal fluctuations throughout the menstrual cycle are delicately balanced and, if altered, can fuel the growth of endometrial tissue outside the confines of the uterus. Below are some of the most critical hormonal influences on endometriosis. 

Estrogen Dominance And Its Effects

One of the fascinating things about endometriosis is that it is known to be dependent on estrogen. If estrogen becomes dominant, outweighing the normal balance, it can significantly contribute to the development and persistence of this condition. When left untreated, elevated estrogen levels trigger inflammation and growth of abnormal endometrial tissue remodeling, exacerbating the painful symptoms of this condition and contributing to its chronic nature.

The Role Of Progesterone In Endometriosis Development

Levels of progesterone increase following ovulation, which helps promote healthy pregnancies and regulate the menstrual cycle. Elevated progesterone levels will balance and prevent overly high estrogen levels and, consequently, the excess growth of endometriosis. This highlights the delicate balance of these two hormones, where low levels of progesterone and increased estrogen levels are thought to play a role in endometriosis simultaneously.

With this in mind, most hormonal treatments for endometriosis revolve around restoring balance with increasing levels of progesterone. However, this is not always effective, and in some cases, the endometriosis growth will persist or even worsen. In this case, it is suggested that endometrial tissue has become resistant to progesterone as a hormone, both naturally occurring and conventional treatments. 

3. Retrograde Menstruation

Retrograde menstruation is a well-established concept of endometriosis development. To be in retrograde is to move backward, and in retrograde menstruation, there is a backward flow of menstrual blood through the fallopian tubes and into the pelvic cavity instead of down and out through the cervix. This process explains how endometrial cells can exit the uterus and go on to implant and grow within the pelvic cavity. 

4. Immune System Disorders

Endometriosis is becoming increasingly explored in the context of autoimmune disease. Although there is limited research, the literature indicates that when specific immune cells malfunction, particularly natural killer (NK) cells, it may contribute to abnormal endometrial tissue growth. These NK cells typically combat viruses and tumors but have been seen to be compromised in people with endometriosis. It’s suggested that when an immune system disorder hinders the body’s defenses, abnormal endometrial tissue can thrive in places beyond the uterus, complicating endometriosis further.

5. Surgical Scar Implantation

Another way that endometrial tissue can develop is by direct transplantation of endometrial cells to organs and tissues outside the uterus, like the abdominal walls. Surgical scar implantation can occur during surgeries such as Cesarean delivery or a hysterectomy. During these procedures, endometrial cells can spread through the pelvis and transfer to surrounding organs, the abdominal wall, or within the surgical incision.

6. Embryonic Cell Transformation

Puberty is a transformative and body-altering phase where estrogen levels surge to prepare for the first menstrual cycle, and it often coincides with the onset of endometriosis. 

Embryonic cell transformation hypothesizes that embryonic stem cells within the abdomen convert into endometrial tissue outside the uterus due to elevated estrogen during puberty. Embryonic cells are wonderfully versatile stem cells that can divide or take on various cell roles during the earliest stages of the human body’s development.

This idea is based on the notion that most abdominal cells and tissues originated from embryonic cells. This intricate process underscores the potential link between embryonic cell transformation and the development of endometriosis.

7. Environmental And Lifestyle Factors

Several environmental and lifestyle factors can have a significant effect on the development of endometriosis. These factors interact with the body’s intricate systems, potentially shaping the course of this complex condition.

Impact Of Environmental Toxins And Pollutants

Being exposed to environmental toxins and pollutants is always considered unsuitable for our overall health and well-being, and it also causes a noteworthy concern when it comes to endometriosis. Suppose you are exposed to elevated levels of these harmful agents throughout your everyday life. In that case, this exposure can contribute to increased levels of inflammation throughout the body and, consequently, the progression of endometriosis. 

Dietary Factors And Endometriosis Risk

It’s evident that our dietary choices can significantly impact many aspects of our health, particularly the development of chronic disease. Processed foods have long been thought to contribute to chronic illness, including endometriosis, as they increase inflammation throughout the body, which can trigger or enhance the growth of endometriosis. 

Additionally, emerging evidence has suggested a potential link between high consumption of red meat as a possible contributor to an increased risk of endometriosis. This could be because red meat may increase the levels of naturally occurring estrogen throughout the body. Further investigation is required to better understand how different foods might be connected to causing endometriosis.

8. Reproductive Health History

There are many significant milestones in a woman’s reproductive health history. Let’s unpack some of them and discuss how they can shape the future risk of endometriosis development. 

Impact Of Early Age Menstruation

Endometriosis can develop any time from your first period until the final stages of menopause. It is suggested that getting your period at a younger age can be a potential risk factor for endometriosis developing as it may lead to longer exposure to hormonal changes. It is important to make a note of any changes to your menstruation so proactive steps can be taken to manage your reproductive health and risk of endometriosis development.

Pregnancy History And Endometriosis Risk

Your reproductive history includes your pregnancy history, and important factors like the number of pregnancies, delivery method, timing, and associated complications can give insights into the increased risk of endometriosis developing. It’s important to remember the whole pregnancy journey can impact the development of this condition, as well as potentially modify its trajectory.

Role Of Childbirth And Breastfeeding In Endometriosis Prevention

Breastfeeding is known to have many positive benefits for both mother and child, and it could even impact the progression of endometriosis. Studies have recently shown that childbirth and an extended duration of breastfeeding can decrease the risk of developing endometriosis and significantly reduce the symptoms. It has been recommended that women be encouraged to breastfeed straight after childbirth and continue for a long duration for positive benefits for those living with endometriosis. 

How Is Endometriosis Diagnosed?

It can be challenging to get an official diagnosis of endometriosis, which leads to delays in timely treatment and increases the risk of complications. A comprehensive approach to diagnosing this complex condition is necessary to ensure all factors are considered. 

Your healthcare provider, typically a gynecologist, will ask questions regarding your medical and reproductive history, as well as your specific symptoms. They will also conduct a physical examination of the abdomen, exploring the areas of tenderness that may indicate endometriosis. 

Additionally, scans such as an ultrasound or MRI may be recommended for a more thorough approach to viewing the surrounding pelvic structures for endometrial growth. These scans give a much more detailed review of the severity of endometriosis.

Furthermore, a surgical laparoscopy may be required, which enables your doctor to explore the pelvis and identify endometrial growth and allow for any targeted removal or tissue sampling that may be required.

Once endometriosis is determined, the initial focus is on managing the distressing symptoms. In the next section, we will explore an innovative approach for addressing endometriosis that doesn’t rely on medications or invasive surgeries. 

How We Approach Endometriosis Pain

When it comes to treatments for endometriosis, it’s essential to consider all approaches so you can be sure you’re making informed decisions that are right for you. The innovative techniques of Neurofunctional Pain Management (NFPM) aim to provide effective relief and enhance the overall well-being of individuals with endometriosis. Various therapies incorporated into the Nueragenex protocol of NFPM can help alleviate pain and manage symptoms, focusing on individualized care. These non-pharmaceutical, non-surgical methods include: 


Electroanalgesia therapy involves the application of specialized electrical currents that can disrupt pain signals and provide effective pain relief. This therapy targets the nerve pathways that signal pain to the brain, reducing pain perception and improving comfort for individuals with endometriosis and its debilitating symptoms. Electroanalgesia offers a non-invasive and non-pharmaceutical option tailored to your specific needs.

IV Therapy

Intravenous (IV) therapy is another aspect of Neurofunctional Pain Management. It involves administering essential nutrients, vitamins, and amino acids directly into the bloodstream, which can be highly beneficial for patients with chronic pain. By addressing deficiencies, IV therapy promotes optimal organ and immune function, ultimately leading to better health outcomes and overall well-being. This therapy is pre-prepared for your individual requirements based on your blood tests. 

Lifestyle Counseling

Neurofunctional Pain Management techniques go beyond treating physical pain. We believe there can be a positive impact on the symptoms of chronic illnesses, including endometriosis, through the adoption of certain lifestyle factors. With the support and guidance of lifestyle counseling, you can integrate these into your daily routine. These elements play an important role in maintaining effective and enduring pain management strategies and contributing to long-term relief.

The three NFPM therapies of electroanalgesia, IV therapy, and lifestyle counseling offer a comprehensive and holistic approach to managing endometriosis-related pain. This patient-centered approach seeks to improve quality of life and empower individuals to take an active role in their pain management journey.

The Neuragenex Protocol For Endometriosis Pain

Endometriosis is a complex condition with a range of potential causes that can individually contribute to developing this challenging condition. The exact trigger may vary, and understanding its possible causes can lead you toward finding the right treatments and pain management solutions. 

At Neuragenex, we offer innovative and tailored solutions to help manage endometriosis-related pain and provide lasting relief. Our Neurofunctional Pain Management techniques offer a whole-person approach that addresses the root causes of pain, supports your overall well-being, and empowers you to regain control of your life. 

Table of Contents